{"id":"W4399141064","doi":"10.1056/nejmc2403986","title":"Phase 3 Trials of Elafibranor and Seladelpar for Primary Biliary Cholangitis","year":2024,"lang":"en","type":"letter","venue":"New England Journal of Medicine","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Liver Centre","funders":"","keywords":"Medicine; Primary sclerosing cholangitis; Internal medicine; Gastroenterology; Biliary tract; Phase (matter); Physics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002307692,0.0006064131,0.001088867,0.000241729,0.0006875863,0.001359794,0.000748152,0.006572688,0.004141639],"category_scores_gemma":[0.003969865,0.0002568918,0.0009724893,0.0002135188,0.000755784,0.0007926441,0.0003927943,0.005408177,0.001539368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001853816,"about_ca_system_score_gemma":0.001076863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009403389,"about_ca_topic_score_gemma":0.003816123,"domain_scores_codex":[0.9990025,0.0005547137,0.00006367037,0.00006782453,0.0001485144,0.0001627957],"domain_scores_gemma":[0.997456,0.001419111,0.0002075519,0.00006808742,0.0001711595,0.0006780345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.09063929,0.003603694,0.008425046,0.001092178,0.0009587455,0.01190212,0.0004200548,0.001890904,0.008476128,0.005506923,0.6222628,0.2448221],"study_design_scores_gemma":[0.2620865,0.03868882,0.0191363,0.001221586,0.0009355522,0.009060344,0.0006854921,0.005266927,0.005488131,0.01793478,0.6393517,0.0001437937],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1477764,0.02283214,0.001380688,0.7564778,0.02475903,0.0009100594,0.001856903,0.0002325839,0.04377441],"genre_scores_gemma":[0.5199139,0.009523625,0.002658937,0.4063648,0.0208253,0.001057518,0.001689431,0.00009530302,0.03787123],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.006572688,"threshold_uncertainty_score":0.0138551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05637303925855509,"score_gpt":0.3464841053235031,"score_spread":0.290111066064948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}