{"id":"W4399157658","doi":"10.21203/rs.3.rs-4432372/v1","title":"Limited Immunogenicity of an HLA-A*03:01-restricted Epitope of Erv-k-env in Non-hiv-1 Settings: Implications for Adoptive Cell Therapy in Cancer","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; National Cancer Institute; Children's National Hospital; George Washington University; U.S. Department of Defense","keywords":"Immunogenicity; Epitope; Human leukocyte antigen; Virology; Human immunodeficiency virus (HIV); Cancer; Adoptive cell transfer; Immunology; Medicine; Cancer research; Antibody; Immune system; T cell; Antigen; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003959768,0.0001643907,0.0001813271,0.00008823684,0.0000994807,0.0004099468,0.0001612977,0.0003099639,0.002124414],"category_scores_gemma":[0.0002869769,0.00007065153,0.0001013137,0.00006629636,0.0002007613,0.0001978764,0.0001256484,0.0003652423,0.000403193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001829677,"about_ca_system_score_gemma":0.0001828453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001650207,"about_ca_topic_score_gemma":0.0001537167,"domain_scores_codex":[0.9998536,0.0000547607,0.00001117792,0.00001712576,0.00003010246,0.0000331414],"domain_scores_gemma":[0.9998708,0.00005472619,0.00002561281,0.00001838769,0.00001278078,0.000017761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003979526,0.00009175306,0.001408687,0.00008342825,0.000005032898,0.0002197972,0.00003697336,0.0001325659,0.9910149,0.0004781107,0.0001690956,0.005961664],"study_design_scores_gemma":[0.00006742401,0.001294927,0.01112612,0.00002594934,0.00003299744,0.002306097,0.0001306961,0.001247515,0.9775619,0.0004579208,0.005743001,0.000005442982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910247,0.002381235,0.002819119,0.0002982082,0.00003382161,0.00002766628,0.0001179484,0.00005153002,0.003245804],"genre_scores_gemma":[0.997034,0.0005583521,0.0007347316,0.00008117043,0.00001208147,0.00001589894,0.0001043265,0.000008387819,0.001451083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002124414,"threshold_uncertainty_score":0.0071069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08717692726774202,"score_gpt":0.4447935036633849,"score_spread":0.3576165763956429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}