{"id":"W4399160561","doi":"10.1039/d4ra03023k","title":"Novel diamine-scaffold based <i>N</i> -acetylgalactosamine (GalNAc)–siRNA conjugate: synthesis and <i>in vivo</i> activities","year":2024,"lang":"en","type":"article","venue":"RSC Advances","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Shandong Provincial Postdoctoral Science Foundation","keywords":"Conjugate; In vivo; Scaffold; Chemistry; Diamine; Cell biology; Combinatorial chemistry; Biophysics; Biomedical engineering; Polymer chemistry; Biology; Medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001209032,0.0003623399,0.0002111325,0.0001182515,0.000106603,0.0002136735,0.0002567458,0.0003088491,0.000595715],"category_scores_gemma":[0.00009356675,0.0001215164,0.0001627242,0.0001145134,0.0001580558,0.0002097864,0.0001531343,0.0002794061,0.0002589601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002792676,"about_ca_system_score_gemma":0.0001884561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004444963,"about_ca_topic_score_gemma":0.0006869733,"domain_scores_codex":[0.9999346,0.00001209897,0.000005861178,0.00001849855,0.00001866831,0.00001029846],"domain_scores_gemma":[0.999941,0.000006650254,0.00002104775,0.000004249142,0.0000110066,0.00001603842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004729597,0.00001259038,0.000051889,0.00004035505,0.000003458009,0.00004556402,0.000009609079,0.00008773268,0.9982116,0.00007374107,0.00003504245,0.001381243],"study_design_scores_gemma":[0.00000507532,0.0001826239,0.0002312167,0.000001037807,0.000005600097,0.00009540883,0.000002430645,0.0004830927,0.9981261,0.000008548083,0.0008557219,0.000003124036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965046,0.002407209,0.02734306,0.0001481326,0.00004015772,0.0001219359,0.0002740153,0.000292185,0.004327305],"genre_scores_gemma":[0.9790738,0.0009358901,0.01562362,0.00007230205,0.00001015809,0.00005664212,0.0003141506,0.00003694948,0.003876549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000595715,"threshold_uncertainty_score":0.0020262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008952513262173247,"score_gpt":0.2410676195140314,"score_spread":0.2321151062518581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}