{"id":"W4399163381","doi":"10.1016/s0140-6736(24)00594-4","title":"Induction-concurrent chemoradiotherapy with or without sintilimab in patients with locoregionally advanced nasopharyngeal carcinoma in China (CONTINUUM): a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Overseas Expertise Introduction Project for Discipline Innovation; Special Project for Research and Development in Key areas of Guangdong Province; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Nasopharyngeal carcinoma; Open label; Medicine; Chemoradiotherapy; Oncology; Internal medicine; Randomized controlled trial; China; Radiation therapy; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001684871,0.001486032,0.003192829,0.0003667245,0.000518175,0.000903349,0.001064216,0.001394532,0.00496136],"category_scores_gemma":[0.001243803,0.0005071476,0.002537484,0.0006673507,0.001451136,0.0009069623,0.0006226526,0.002588127,0.0007171014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001204008,"about_ca_system_score_gemma":0.002023322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002767751,"about_ca_topic_score_gemma":0.005868601,"domain_scores_codex":[0.9994321,0.0002720284,0.00003345386,0.0001100875,0.00003524863,0.0001169284],"domain_scores_gemma":[0.9993048,0.0001340356,0.0001619469,0.00008480551,0.00004565857,0.0002688108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9702969,0.006406103,0.001102217,0.0008588494,0.001057483,0.00003470287,0.00008668667,0.0003946021,0.00158131,0.0001051987,0.0008213064,0.01725466],"study_design_scores_gemma":[0.9529613,0.04399251,0.001845482,0.0000283248,0.0003935363,0.00001382779,0.00002596356,0.0001403015,0.000155716,0.00008327363,0.0003510767,0.000008644346],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906284,0.003571057,0.0003276072,0.0004583354,0.0004493962,0.002673659,0.0006013073,0.00007515617,0.001215058],"genre_scores_gemma":[0.9879208,0.002583437,0.001039251,0.001051155,0.0002977026,0.003444103,0.001137816,0.0000146087,0.002511157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00496136,"threshold_uncertainty_score":0.01659745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03766731193373148,"score_gpt":0.339211229324541,"score_spread":0.3015439173908095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}