{"id":"W4399163381","doi":"10.1016/s0140-6736(24)00594-4","title":"Induction-concurrent chemoradiotherapy with or without sintilimab in patients with locoregionally advanced nasopharyngeal carcinoma in China (CONTINUUM): a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Overseas Expertise Introduction Project for Discipline Innovation; Special Project for Research and Development in Key areas of Guangdong Province; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Nasopharyngeal carcinoma; Open label; Medicine; Chemoradiotherapy; Oncology; Internal medicine; Randomized controlled trial; China; Radiation therapy; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004872473,0.0003804382,0.002041876,0.0001343116,0.00008789936,0.00009437397,0.0003006133,0.00007084644,0.00007693395],"category_scores_gemma":[0.00007544802,0.0001826374,0.00006203398,0.0004792836,0.0001756456,0.0002569521,0.0000524274,0.000511039,0.000005776604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002165449,"about_ca_system_score_gemma":0.0003112037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001539812,"about_ca_topic_score_gemma":0.001418546,"domain_scores_codex":[0.9978209,0.0001650752,0.000532684,0.000551204,0.0004016978,0.000528432],"domain_scores_gemma":[0.9990387,0.0002080039,0.0001512154,0.0004107554,0.00008187049,0.0001094648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9472172,0.002285878,0.02911153,0.0001490956,0.0003376392,0.0001399427,0.001948668,0.00001202032,0.00007908882,0.00003063103,0.001073701,0.01761456],"study_design_scores_gemma":[0.9538739,0.006164923,0.03475647,0.0009331499,0.000160944,0.0000171519,0.0001413728,0.00145559,0.00002964088,0.00001016964,0.002184334,0.0002723543],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845542,0.0027681,0.00003999219,0.002499425,0.000403713,0.009108877,0.00003063128,0.00006535717,0.0005296869],"genre_scores_gemma":[0.995837,0.0003811671,0.0005156079,0.0005700388,0.0006572279,0.001570676,0.00004980312,0.00005608437,0.0003624117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0173422,"threshold_uncertainty_score":0.7447736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03766731193373148,"score_gpt":0.339211229324541,"score_spread":0.3015439173908095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}