{"id":"W4399172435","doi":"10.1007/s40262-024-01367-2","title":"Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population","year":2024,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Duke Clinical Research Institute; National Institute of Child Health and Human Development; National Institutes of Health","keywords":"Levetiracetam; Pharmacokinetics; Medicine; Obesity; Disposition; Pediatrics; Population; Age groups; Pharmacology; Epilepsy; Internal medicine; Demography; Psychology; Psychiatry; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009298471,0.0001166294,0.0002784739,0.0000724367,0.00003209272,0.000008747647,0.0001567638,0.00005434991,0.00001051708],"category_scores_gemma":[0.000433587,0.00005326176,0.0001128044,0.0004271937,0.00009959611,0.00001961675,0.0000441453,0.0003247162,0.000003195827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001565789,"about_ca_system_score_gemma":0.0000261877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002447789,"about_ca_topic_score_gemma":8.710726e-7,"domain_scores_codex":[0.9983699,0.0004098504,0.0005406145,0.0002176167,0.0003268943,0.0001351785],"domain_scores_gemma":[0.9969172,0.002564761,0.0001105261,0.0002590523,0.0000870456,0.00006143687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004329835,0.006992394,0.3672008,0.00594477,0.0003569024,0.0001116113,0.0009334697,0.005828608,0.4939646,0.001498794,0.0006301531,0.112208],"study_design_scores_gemma":[0.001176345,0.001352133,0.8590332,0.0001868033,0.0003621906,0.00000136172,0.00001204649,0.1329711,0.004534071,0.0002833145,0.00002948782,0.00005798228],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946676,0.0003603086,0.001033287,0.002213531,0.00008745703,0.001576566,0.0000191877,0.00001112434,0.00003092609],"genre_scores_gemma":[0.9981537,0.0008258113,0.00009066211,0.0006128093,0.0001712495,0.00009532282,0.00003460425,0.00001004497,0.000005733645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4918323,"threshold_uncertainty_score":0.2171951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06324273030691942,"score_gpt":0.3990396598029761,"score_spread":0.3357969294960567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}