{"id":"W4399173358","doi":"10.3390/ijms25115964","title":"Sex-Based Mechanisms of Cardiac Development and Function: Applications for Induced-Pluripotent Stem Cell Derived-Cardiomyocytes","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Stem Cell Network","keywords":"Induced pluripotent stem cell; Biology; Stem cell; Sexual dimorphism; Hormone; Sexual differentiation; Bioinformatics; Sex characteristics; Disease; Cardiac function curve; Cardiovascular physiology; Cardiac cell; Cell type; Sex hormone-binding globulin; Physiology; Function (biology); Heart development; Stem cell biology; Cell; Heart failure; Internal medicine; Evolutionary biology; Medicine; Endocrinology; Genetics; Cell biology; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006939922,0.000309098,0.0002393112,0.0004120841,0.0001288694,0.0004460379,0.0002988948,0.0004767097,0.001212309],"category_scores_gemma":[0.0002378173,0.0001353315,0.0003292669,0.0002344716,0.0002966597,0.0003215604,0.0003714587,0.0006577229,0.0002158694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936433,"about_ca_system_score_gemma":0.0001898953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001681492,"about_ca_topic_score_gemma":0.0003200458,"domain_scores_codex":[0.9998216,0.00004385761,0.00001556404,0.00003448844,0.00006729468,0.00001710826],"domain_scores_gemma":[0.9999129,0.00003419704,0.00001462586,0.000009639253,0.0000171485,0.00001151056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009861403,0.00005163516,0.000924675,0.0007986617,0.00002600363,0.0003278439,0.0001345522,0.0005302129,0.8742855,0.004897265,0.0007764417,0.1171485],"study_design_scores_gemma":[0.00006027054,0.001403228,0.01133192,0.0003392522,0.0002474622,0.002664367,0.0003361848,0.005727995,0.8655658,0.006058508,0.1062142,0.00005086607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2451252,0.4640899,0.2544178,0.004316829,0.001421707,0.000604594,0.001584464,0.001141368,0.0272981],"genre_scores_gemma":[0.7540519,0.1785982,0.05988546,0.0007609354,0.0002865344,0.0003345195,0.0007146149,0.00006899265,0.005298884],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001212309,"threshold_uncertainty_score":0.00405556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01601022221667454,"score_gpt":0.2679775404363623,"score_spread":0.2519673182196878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}