{"id":"W4399177113","doi":"10.3389/fphar.2024.1308547","title":"Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery","year":2024,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"In vivo; Hazard ratio; Drug; Medicine; Drug discovery; Pharmacology; Drug development; Bioinformatics; Computational biology; Neuroscience; Biology; Internal medicine; Confidence interval; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003198244,0.0002185358,0.0003295543,0.0006077734,0.00005881365,0.00007712978,0.0004558535,0.00005838995,0.000001344387],"category_scores_gemma":[0.00003355271,0.0002218995,0.00007223112,0.0007968216,0.00005875887,0.0007483693,0.0001307209,0.0004012365,0.000002899263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003400825,"about_ca_system_score_gemma":0.0002995628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001257297,"about_ca_topic_score_gemma":0.00001492729,"domain_scores_codex":[0.9977531,0.0001171572,0.0006393347,0.0007356565,0.0002719926,0.0004827124],"domain_scores_gemma":[0.999553,0.0001340716,0.0001043354,0.0001175601,0.00001068942,0.00008039775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001302755,0.00008136999,0.0009800362,0.0002891358,0.000003543382,0.00009563795,0.00136238,0.0009776052,0.9934681,0.00005989518,0.001231006,0.001320994],"study_design_scores_gemma":[0.0008024352,0.00003316576,0.01368752,0.00008982123,0.00001405022,0.00000816039,0.00007955266,0.01207336,0.9723799,0.00003132426,0.0006059101,0.0001948144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905834,0.00009461582,0.001934504,0.0001606017,0.006381981,0.0007068631,0.00001682422,0.00006774791,0.00005352417],"genre_scores_gemma":[0.9980875,0.00004643718,0.0009520923,0.0002258231,0.00008856881,0.0001342931,0.000003108358,0.00002839804,0.0004337777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02108824,"threshold_uncertainty_score":0.9048797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02244158432255418,"score_gpt":0.2882111342311526,"score_spread":0.2657695499085984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}