{"id":"W4399188064","doi":"10.1016/j.phrs.2024.107242","title":"Discovery of a CCR2-targeting pepducin therapy for chronic pain","year":2024,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"CCR2; Neuropathic pain; Medicine; Chemokine receptor; Chronic pain; Cancer pain; Opioid; Chemokine; Pharmacology; Receptor; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008047,0.0003332435,0.0002997549,0.000201322,0.0001050531,0.000338073,0.0002539069,0.0003355199,0.00115735],"category_scores_gemma":[0.00008759951,0.00009458051,0.0002298711,0.0001151546,0.0001990204,0.0003321955,0.0001859339,0.0007849584,0.0002023942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001906371,"about_ca_system_score_gemma":0.0002000827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001529294,"about_ca_topic_score_gemma":0.000336842,"domain_scores_codex":[0.9999368,0.00001137431,0.000003823951,0.00001234782,0.00001349051,0.00002212284],"domain_scores_gemma":[0.9999679,0.000003456533,0.00001018162,0.000002516857,0.000005194881,0.00001068997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003649511,0.0005398736,0.0002226757,0.0003165617,0.00002236624,0.0002237812,0.0000343175,0.0005152863,0.9640843,0.001457415,0.0006470077,0.03157152],"study_design_scores_gemma":[0.001927749,0.03206792,0.009633897,0.0002369997,0.0002338718,0.00260666,0.000105927,0.01011614,0.8823501,0.001214717,0.0594505,0.00005551723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9358204,0.02083454,0.0342788,0.00176744,0.0003300398,0.0006638896,0.0005809834,0.0003841404,0.00533972],"genre_scores_gemma":[0.9798397,0.008037117,0.008903237,0.0004329757,0.00007201886,0.0002216584,0.000341356,0.00001660267,0.002135206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00115735,"threshold_uncertainty_score":0.003871679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2018987923797238,"score_gpt":0.5156125775184907,"score_spread":0.3137137851387669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}