{"id":"W4399201500","doi":"10.1182/blood.2023023707","title":"Interleukin-1–mediated hyperinflammation in XIAP deficiency is associated with defective autophagy","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Autophagy; Immunology; Medicine; XIAP; Interleukin; Cancer research; Biology; Cytokine; Apoptosis; Programmed cell death; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001907066,0.0004080256,0.0001716846,0.0002793854,0.0001116209,0.0001844797,0.00010861,0.0002770538,0.0009339823],"category_scores_gemma":[0.0001842351,0.0001097641,0.0001483595,0.0001646376,0.0003117797,0.000121734,0.0002642885,0.0003621921,0.0002509862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001301229,"about_ca_system_score_gemma":0.00008784301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000854641,"about_ca_topic_score_gemma":0.0001009312,"domain_scores_codex":[0.9998976,0.00002680767,0.00001779256,0.00002297572,0.0000162746,0.00001855175],"domain_scores_gemma":[0.9998378,0.00002794758,0.00007813403,0.0000178238,0.000007170956,0.00003111456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006429213,0.0000593535,0.009020871,0.00009439939,0.00002081933,0.01044303,0.00007883604,0.00007829501,0.976645,0.0001395014,0.00009664548,0.002680383],"study_design_scores_gemma":[0.000124479,0.00155166,0.1388241,0.0000352362,0.0001128524,0.1679276,0.0001683623,0.001366906,0.6856093,0.0003947066,0.003868368,0.00001644441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982342,0.0004677821,0.0007905104,0.00003573704,0.000007219923,0.000009234035,0.00005917353,0.00003051156,0.0003656979],"genre_scores_gemma":[0.9990991,0.0001644376,0.0004526325,0.00001527383,0.000007679064,0.000005827756,0.0000681843,0.000003718381,0.0001831455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009339823,"threshold_uncertainty_score":0.003124475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213346500369091,"score_gpt":0.2634141348774849,"score_spread":0.251280669873794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}