{"id":"W4399201500","doi":"10.1182/blood.2023023707","title":"Interleukin-1–mediated hyperinflammation in XIAP deficiency is associated with defective autophagy","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Autophagy; Immunology; Medicine; XIAP; Interleukin; Cancer research; Biology; Cytokine; Apoptosis; Programmed cell death; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003011695,0.0001521606,0.0002736223,0.0002663139,0.00004690498,0.0000488558,0.00008480492,0.0001220154,0.0003042898],"category_scores_gemma":[0.0002736772,0.0001191856,0.00006884417,0.0007785364,0.00007600303,0.0001727368,0.00003841807,0.0003703872,0.0002677254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001181112,"about_ca_system_score_gemma":0.0003541136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004267553,"about_ca_topic_score_gemma":0.00003728169,"domain_scores_codex":[0.9986804,0.00005761076,0.0002931159,0.0002966758,0.0003461388,0.0003261004],"domain_scores_gemma":[0.9994873,0.0001140449,0.00004168006,0.0001937157,0.00009824138,0.00006498121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001722244,0.01045864,0.4399772,0.003530935,0.003440194,0.01120397,0.0509901,0.0001056105,0.3924235,0.005879282,0.004892157,0.07537622],"study_design_scores_gemma":[0.01829876,0.003371573,0.7695823,0.003372892,0.0005821019,0.0004526045,0.002462324,0.01045171,0.1809676,0.000621632,0.008823465,0.001013124],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984069,0.002082745,0.00003862182,0.0002621876,0.00005010254,0.0004178355,0.000007122522,0.0002059652,0.01286642],"genre_scores_gemma":[0.9986153,0.00009296046,0.00002901161,0.00009820815,0.00002607809,0.00006632978,0.00005345299,0.00003298028,0.0009856314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.329605,"threshold_uncertainty_score":0.4860247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213346500369091,"score_gpt":0.2634141348774849,"score_spread":0.251280669873794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}