{"id":"W4399203954","doi":"10.1016/j.eclinm.2024.102655","title":"Once-daily upadacitinib versus placebo in adults with extensive non-segmental vitiligo: a phase 2, multicentre, randomised, double-blind, placebo-controlled, dose-ranging study","year":2024,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"AbbVie","keywords":"Medicine; Dose-ranging study; Placebo; Vitiligo; Double blind; Dermatology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00293278,0.001845375,0.004059881,0.0006654068,0.0005619188,0.001101786,0.001092652,0.00209224,0.006680151],"category_scores_gemma":[0.002130779,0.001024623,0.002050038,0.0005741518,0.001134139,0.001368594,0.0005332532,0.003017474,0.001009755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007414108,"about_ca_system_score_gemma":0.001301675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006820724,"about_ca_topic_score_gemma":0.001751279,"domain_scores_codex":[0.9988827,0.0005922646,0.00008121446,0.0001847043,0.00009598128,0.0001631834],"domain_scores_gemma":[0.9985735,0.0003944896,0.0003465731,0.0001109635,0.0001442149,0.0004303373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9623774,0.02027144,0.0004769993,0.0006604454,0.0005265786,0.00003440004,0.00006805455,0.000196274,0.004296269,0.00003591278,0.0003913041,0.0106648],"study_design_scores_gemma":[0.82471,0.1726582,0.001510731,0.00002093881,0.000279377,0.00002473245,0.00001824751,0.0001672498,0.0002904349,0.00003516196,0.0002742544,0.00001060611],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983718,0.003969954,0.0006456841,0.0004300333,0.0004222064,0.008633092,0.0007609905,0.0001093763,0.001310685],"genre_scores_gemma":[0.9838186,0.002548194,0.00175686,0.001001562,0.0005281736,0.007574053,0.0006052688,0.00001935263,0.002147834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006680151,"threshold_uncertainty_score":0.02234739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02614453032974624,"score_gpt":0.356416092743539,"score_spread":0.3302715624137928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}