{"id":"W4399213350","doi":"10.1158/2159-8290.cd-23-1092","title":"CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i> - and <i>TET2</i> -mutant Cells","year":2024,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; National Institute on Aging; Geoffrey Beene Foundation; Syndax Pharmaceuticals; Leukemia Research Foundation; “la Caixa” Foundation; Daiichi-Sankyo","keywords":"Biology; Haematopoiesis; Progenitor cell; Cell biology; Ex vivo; Mutant; Bone marrow; Stem cell; CRISPR; Cancer research; Genetics; Immunology; In vivo; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761197,0.0004126171,0.0002980104,0.0002988509,0.0002817621,0.0003852705,0.0003520429,0.000472204,0.003023222],"category_scores_gemma":[0.0001705189,0.000176765,0.0003743595,0.0002036983,0.0003585648,0.000130557,0.0004434283,0.0009522869,0.001038786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003854717,"about_ca_system_score_gemma":0.0002935936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249064,"about_ca_topic_score_gemma":0.003302973,"domain_scores_codex":[0.9997396,0.00002253432,0.00002849741,0.00006998908,0.0001037996,0.0000356378],"domain_scores_gemma":[0.9998093,0.00003934323,0.00006301539,0.00003254367,0.00001414944,0.00004158344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002499693,0.00001165218,0.0003181309,0.0000239912,0.000006497716,0.00007687586,0.000009169454,0.0001126446,0.9980959,0.0000951333,0.00009831429,0.001126683],"study_design_scores_gemma":[0.000008198162,0.00007534677,0.006077878,0.000007988176,0.00002116641,0.0005161571,0.00002275454,0.001219359,0.987542,0.00008027448,0.004420253,0.000008602209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9427139,0.0008671861,0.03872977,0.0004040751,0.00009781361,0.0002008158,0.009291611,0.001812598,0.005882346],"genre_scores_gemma":[0.9755026,0.000461323,0.0142381,0.0002770406,0.000007036576,0.0001162158,0.003495896,0.0003421943,0.005559658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003023222,"threshold_uncertainty_score":0.01011372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0212914711013381,"score_gpt":0.307616695401961,"score_spread":0.2863252243006229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}