{"id":"W4399213350","doi":"10.1158/2159-8290.cd-23-1092","title":"CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i> - and <i>TET2</i> -mutant Cells","year":2024,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; National Institute on Aging; Geoffrey Beene Foundation; Syndax Pharmaceuticals; Leukemia Research Foundation; “la Caixa” Foundation; Daiichi-Sankyo","keywords":"Biology; Haematopoiesis; Progenitor cell; Cell biology; Ex vivo; Mutant; Bone marrow; Stem cell; CRISPR; Cancer research; Genetics; Immunology; In vivo; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001015615,0.0005028504,0.0008927746,0.0005099251,0.00008573585,0.0003605274,0.0003508757,0.000304144,0.0001982778],"category_scores_gemma":[0.00002219655,0.0004490299,0.000199048,0.001367202,0.0003294744,0.0008869639,0.0003902199,0.00152084,0.0002172106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002389192,"about_ca_system_score_gemma":0.00174697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205529,"about_ca_topic_score_gemma":0.0005529785,"domain_scores_codex":[0.9956045,0.0002427833,0.0008801942,0.001393824,0.0008925567,0.0009861885],"domain_scores_gemma":[0.9981838,0.0003956317,0.00008672919,0.0008984395,0.00009344934,0.0003419151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001618557,0.0005836085,0.02226295,0.006363956,0.0001708655,0.00805553,0.003710276,0.0001961732,0.9246932,0.0005258436,0.01792313,0.01389589],"study_design_scores_gemma":[0.0117339,0.0008154379,0.0368485,0.01004176,0.0004060749,0.0009786163,0.003947226,0.001043469,0.8827757,0.003318086,0.04556675,0.002524496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9479246,0.04452194,0.0003197262,0.001273377,0.0007913727,0.001507325,0.0002213234,0.0001142249,0.003326133],"genre_scores_gemma":[0.9761386,0.01886489,0.0001131615,0.001122638,0.0003083624,0.0002674512,0.00003379389,0.0001253221,0.003025769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04191754,"threshold_uncertainty_score":0.9997962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0212914711013381,"score_gpt":0.307616695401961,"score_spread":0.2863252243006229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}