{"id":"W4399217048","doi":"10.3390/antiox13060667","title":"Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species","year":2024,"lang":"en","type":"article","venue":"Antioxidants","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Fluconazole; Reactive oxygen species; Pharmacology; Microbiology; Fungicide; Candida albicans; Biology; Chemistry; Biochemistry; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009513046,0.0002049924,0.0002041132,0.0002258485,0.0001344646,0.0001501544,0.0001678856,0.0001848008,0.00116136],"category_scores_gemma":[0.00008612918,0.00006565895,0.0001417812,0.0001823233,0.000119085,0.00009557018,0.0001582851,0.0003490973,0.0001037603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641892,"about_ca_system_score_gemma":0.000288645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110755,"about_ca_topic_score_gemma":0.003100737,"domain_scores_codex":[0.9999336,0.00001100305,0.000004968069,0.00001177011,0.00002283719,0.00001577926],"domain_scores_gemma":[0.9999533,0.000006458075,0.00001568053,0.000004779302,0.000007502137,0.00001220644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002195167,0.00006854723,0.0002848613,0.00008198969,0.000007490445,0.00006902367,0.00001291501,0.00009568714,0.9923878,0.0001011109,0.00008580834,0.006585347],"study_design_scores_gemma":[0.00007270521,0.00278959,0.005920794,0.00001249178,0.00006237231,0.0003327763,0.00001826155,0.0006096719,0.9824614,0.00004322848,0.007670371,0.00000624602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936786,0.002718196,0.0010891,0.0001353758,0.00003191542,0.00003742877,0.0002490766,0.00005499664,0.002005373],"genre_scores_gemma":[0.993515,0.001942517,0.001703736,0.00006670588,0.0000165357,0.0000221818,0.0002978042,0.000006484705,0.002428901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00116136,"threshold_uncertainty_score":0.00388515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02843938232670033,"score_gpt":0.2541570241626462,"score_spread":0.2257176418359459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}