{"id":"W4399218247","doi":"10.1200/jco.24.00581","title":"Lorlatinib Versus Crizotinib in Patients With Advanced <i>ALK</i> -Positive Non–Small Cell Lung Cancer: 5-Year Outcomes From the Phase III CROWN Study","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":313,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Genentech; Grifols; Lunit; Sociedad Española de Oncología Médica; BeiGene; Taiho Pharmaceutical; Jazz Pharmaceuticals; Regeneron Pharmaceuticals; Gilead Sciences; Daiichi Sankyo Europe; Sanofi; GlaxoSmithKline; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Crizotinib; Medicine; Lung cancer; Internal medicine; Oncology; ALK inhibitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006336066,0.0001870569,0.001082814,0.0000811808,0.00006090284,0.00002494901,0.0001540306,0.0001349588,0.000158092],"category_scores_gemma":[0.000328907,0.00009586356,0.0002565792,0.0002116233,0.000101104,0.000140021,0.00004257818,0.0008930327,0.000008185379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003585403,"about_ca_system_score_gemma":0.001907969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002621796,"about_ca_topic_score_gemma":0.000561389,"domain_scores_codex":[0.9975016,0.0002302376,0.001415793,0.0002733232,0.0003538353,0.0002252329],"domain_scores_gemma":[0.9954353,0.003184414,0.0006553892,0.0001999657,0.0003196508,0.0002052576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02596984,0.0079272,0.877073,0.00001755961,0.002086489,0.0006644361,0.002858109,0.00008209845,0.000005852109,0.00000824,0.001694543,0.08161263],"study_design_scores_gemma":[0.1259542,0.02768864,0.83566,0.0002707853,0.002995586,0.000001976074,0.001571054,0.00007681934,0.00001390065,0.0000103598,0.005642354,0.000114306],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895454,0.0007206321,0.00005155528,0.003145871,0.002630524,0.001047513,0.0000730552,0.00001209963,0.002773357],"genre_scores_gemma":[0.9972221,0.0001592207,0.0007424542,0.001058437,0.0005043701,0.00003575871,0.00001853228,0.00002695351,0.0002322368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09998433,"threshold_uncertainty_score":0.3909203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04732648856136055,"score_gpt":0.475723419983027,"score_spread":0.4283969314216664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}