{"id":"W4399230623","doi":"10.1007/s00018-024-05284-2","title":"The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development","year":2024,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Spanish National Plan for Scientific and Technical Research and Innovation; Agencia Estatal de Investigación; European Regional Development Fund; Generalitat Valenciana; Fundación Ramón Areces; Ministerio de Ciencia e Innovación; Consejo Superior de Investigaciones Científicas; Government of Canada; Canada Excellence Research Chairs, Government of Canada","keywords":"Syncytiotrophoblast; Cell biology; Trophoblast; Biology; Placentation; Cellular differentiation; Endoplasmic reticulum; Wnt signaling pathway; Placenta; Signal transduction; Gene; Genetics; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000160748,0.0003671616,0.0002203535,0.0004425752,0.0002954719,0.0005613567,0.0001442403,0.0004048844,0.001637837],"category_scores_gemma":[0.0002821322,0.0002193554,0.0002835845,0.0003169417,0.0002416283,0.0002874306,0.0005834984,0.000598312,0.0007515516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004053372,"about_ca_system_score_gemma":0.0004345261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006436868,"about_ca_topic_score_gemma":0.0005001384,"domain_scores_codex":[0.9997995,0.00002762993,0.00002133854,0.00005028626,0.00006482741,0.00003643403],"domain_scores_gemma":[0.999831,0.00001686015,0.00006209357,0.0000187714,0.00002507822,0.00004630192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009885905,0.000006571314,0.001572067,0.00007018779,0.000009841707,0.0006176043,0.00005042345,0.00008438004,0.9921969,0.0005784593,0.0001683747,0.004546357],"study_design_scores_gemma":[0.00003761052,0.0002433344,0.08088163,0.00007248456,0.00007539157,0.004452358,0.0002679795,0.002058507,0.8645452,0.001517256,0.04581958,0.00002871103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542323,0.01063343,0.02290907,0.0007118031,0.0001044913,0.00008486322,0.003017737,0.000804905,0.00750147],"genre_scores_gemma":[0.9819537,0.005239921,0.00528228,0.0001249078,0.00002372693,0.00005875973,0.00226149,0.00008786382,0.004967256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001637837,"threshold_uncertainty_score":0.005479157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772195084528223,"score_gpt":0.2661247917502187,"score_spread":0.2484028409049365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}