{"id":"W4399236994","doi":"10.1016/j.reth.2024.05.007","title":"A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic","year":2024,"lang":"en","type":"article","venue":"Regenerative Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Ministry of Health, Labour and Welfare; New Energy and Industrial Technology Development Organization; Japan Society for the Promotion of Science; Alberta Innovates - Health Solutions","keywords":"Mesenchymal stem cell; Scaffold; Articular cartilage; Cartilage; Stem cell; Tissue engineering; Cell biology; Medicine; Biomedical engineering; Anatomy; Pathology; Biology; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529139,0.0003731576,0.0003336049,0.0005330106,0.0001436141,0.0004163409,0.0002818225,0.0004304246,0.0009521596],"category_scores_gemma":[0.00008747254,0.0001349184,0.0003662785,0.0002960011,0.0001966317,0.0004168023,0.0002650521,0.0003997668,0.0005017431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001588798,"about_ca_system_score_gemma":0.0003812335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002578387,"about_ca_topic_score_gemma":0.0006233842,"domain_scores_codex":[0.9999002,0.00001013426,0.00001122897,0.00001612651,0.00005265371,0.000009638452],"domain_scores_gemma":[0.9999651,0.000005581368,0.00001014689,0.000002049819,0.000009525943,0.000007628469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006079467,0.00005767287,0.000172331,0.001626277,0.00002717615,0.0004481369,0.00007518983,0.0005220225,0.928732,0.001773888,0.000741413,0.06576319],"study_design_scores_gemma":[0.0000446312,0.001212589,0.002976222,0.0002539063,0.000276954,0.004184115,0.00008722129,0.00308601,0.8372111,0.0009573627,0.1496414,0.00006844608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.357521,0.3494466,0.2610671,0.001361299,0.001112486,0.0005473149,0.001443347,0.001679168,0.02582163],"genre_scores_gemma":[0.6889275,0.1507805,0.141344,0.001032944,0.0002776812,0.0003651075,0.001132639,0.0001622442,0.01597744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009521596,"threshold_uncertainty_score":0.003185272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03461833509240515,"score_gpt":0.2901563464556076,"score_spread":0.2555380113632024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}