{"id":"W4399245549","doi":"10.1016/j.ymthe.2024.05.037","title":"Activation of nicotinic acetylcholine receptor α7 subunit limits Zika viral infection via promoting autophagy and ferroptosis","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Science and Technology Commission of Shanghai Municipality; Chinese Academy of Sciences; National Natural Science Foundation of China; National Key Research and Development Program of China; Innovative Research Team of High-level Local University in Shanghai","keywords":"Nicotinic acetylcholine receptor; Acetylcholine receptor; Virology; Protein subunit; Viral infection; Autophagy; Receptor; Biology; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618287,0.0001595504,0.0002479324,0.0001284434,0.00004574658,0.00003812726,0.0000428358,0.0000985037,0.0001560053],"category_scores_gemma":[0.00004610038,0.0001371016,0.000141826,0.0002442169,0.00003339109,0.0001027141,0.00001539097,0.0001645495,0.00001271361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003997957,"about_ca_system_score_gemma":0.0000612802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005291552,"about_ca_topic_score_gemma":0.000001507484,"domain_scores_codex":[0.9990054,0.00007792526,0.0002460777,0.0002872875,0.0002057942,0.000177558],"domain_scores_gemma":[0.9995034,0.00003055192,0.00007125911,0.0002138568,0.00009063559,0.00009033301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002616837,0.0001527617,0.001257072,0.0001411167,0.0001852281,0.000005757091,0.0002407095,0.000007819,0.8117459,0.0001597563,0.00003784052,0.1858043],"study_design_scores_gemma":[0.002449253,0.001035486,0.01662384,0.000353578,0.0001502594,0.00001656004,0.0000216239,0.008986793,0.9644019,0.0001671308,0.00559754,0.0001960059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904835,0.003950136,0.003650856,0.00101215,0.0001364191,0.0005248949,0.000005002072,0.0001173549,0.0001197488],"genre_scores_gemma":[0.9983197,0.000635892,0.0001518046,0.0004406727,0.0001389262,0.00004809346,0.0000514299,0.00004290517,0.0001705033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1856083,"threshold_uncertainty_score":0.5590842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195447613695214,"score_gpt":0.2808720577665523,"score_spread":0.2689175816296001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}