{"id":"W4399256985","doi":"10.1007/s12264-024-01218-x","title":"Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer’s Disease: A Data-Driven Meta-Analysis with N = 3,118","year":2024,"lang":"en","type":"review","venue":"Neuroscience Bulletin","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Genentech; IXICO; National Natural Science Foundation of China; Fundamental Research Funds for the Central Universities; Northern California Institute for Research and Education; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Pfizer; National Institute on Aging; Alzheimer's Association","keywords":"Neuroimaging; Cognitive impairment; Meta-analysis; Disease; Cognition; Psychology; Alzheimer's disease; Neuroscience; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008591161,0.00141866,0.005255163,0.002032839,0.0003474796,0.001390322,0.001041778,0.0009366004,0.00154507],"category_scores_gemma":[0.01081759,0.0005838767,0.01605047,0.003588721,0.0002871918,0.0006459794,0.001009483,0.001164961,0.0001935118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000719087,"about_ca_system_score_gemma":0.001576553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003713193,"about_ca_topic_score_gemma":0.009548565,"domain_scores_codex":[0.9965754,0.002114534,0.0004479739,0.0004890839,0.0002570727,0.0001158773],"domain_scores_gemma":[0.9942098,0.004639422,0.0004043586,0.0002961133,0.0003345996,0.0001156963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003294536,0.0000366572,0.03801201,0.05936196,0.8428436,0.0002935965,0.00007417779,0.001342314,0.001172074,0.0004387633,0.002059026,0.05107128],"study_design_scores_gemma":[0.0006134682,0.0002653573,0.03917275,0.003899823,0.9471267,0.0002693315,0.0000507413,0.0007353115,0.0003268049,0.001276467,0.00622736,0.00003574225],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01632145,0.9790915,0.002168561,0.0004913092,0.0001627668,0.00008554744,0.001344215,0.00003887509,0.0002958467],"genre_scores_gemma":[0.4551798,0.5311757,0.007033848,0.001134646,0.0003627871,0.0004845067,0.00403678,0.00007587638,0.0005159919],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008591161,"threshold_uncertainty_score":0.04543495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09573486462255151,"score_gpt":0.3454268181207627,"score_spread":0.2496919534982112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}