{"id":"W4399261913","doi":"10.1007/s12035-024-04255-9","title":"Pyroptosis Signature Gene CHMP4B Regulates Microglia Pyroptosis by Inhibiting GSDMD in Alzheimer’s Disease","year":2024,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Education and Child Care","funders":"National Natural Science Foundation of China","keywords":"Pyroptosis; Microglia; Disease; Neuroscience; Alzheimer's disease; Signature (topology); Biology; Medicine; Chemistry; Immunology; Inflammation; Pathology; Inflammasome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002641225,0.0004416641,0.0004510169,0.0003684289,0.0003001,0.0004272179,0.000306627,0.0003941329,0.002011926],"category_scores_gemma":[0.0001985837,0.0002731833,0.0003979931,0.0001993802,0.000626307,0.0002552083,0.0003068644,0.001185435,0.0004250248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004538151,"about_ca_system_score_gemma":0.0003930376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007734745,"about_ca_topic_score_gemma":0.001166104,"domain_scores_codex":[0.9997757,0.00003221538,0.00002516955,0.00004875463,0.00004129119,0.00007698644],"domain_scores_gemma":[0.9998969,0.000009117051,0.0000316424,0.00001224666,0.00001184558,0.00003834771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002168883,0.0001120934,0.0005805446,0.0001041294,0.00002773334,0.0001340356,0.00002566882,0.0001218705,0.9936412,0.0002371965,0.0002431658,0.002603525],"study_design_scores_gemma":[0.0005219802,0.0008718054,0.01767568,0.00002611039,0.0001276136,0.0005801083,0.0001512613,0.001664251,0.9722435,0.0004731618,0.005644135,0.00002034228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99213,0.002830717,0.002237187,0.000440388,0.000156044,0.00003756542,0.0007707168,0.0001709799,0.001226482],"genre_scores_gemma":[0.9943626,0.0009277877,0.001785401,0.0001518229,0.00002197364,0.00006939213,0.0005479445,0.00003117041,0.002101975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002011926,"threshold_uncertainty_score":0.006730556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004568722346101905,"score_gpt":0.2188826301416646,"score_spread":0.2143139077955627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}