{"id":"W4399271346","doi":"10.1093/brain/awae176","title":"Towards cascading genetic risk in Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research, Development and Innovation Office; National Health and Medical Research Council; Medical Research Council; Medical Research Council Canada; Ministero della Salute; Alzheimer’s Research UK; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; ZonMw; Wolfson Foundation; British Heart Foundation; University College London; UK Research and Innovation; Brain Research UK; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Weston Brain Institute; Agence Nationale de la Recherche; Wellcome Trust; Alzheimer's Disease Neuroimaging Initiative; National Institute on Aging; Alzheimer's Association","keywords":"Hazard ratio; Neurodegeneration; Apolipoprotein E; Alzheimer's Disease Neuroimaging Initiative; Disease; Oncology; Alzheimer's disease; Biomarker; Internal medicine; Proportional hazards model; Cohort; Confidence interval; Medicine; Allele; Psychology; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008503154,0.001462724,0.001121918,0.001715307,0.0005899632,0.001926818,0.001264889,0.001312535,0.003760437],"category_scores_gemma":[0.01846271,0.0008983737,0.002475533,0.001567881,0.001628509,0.001841566,0.002704184,0.002415028,0.0004480503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004613767,"about_ca_system_score_gemma":0.0009780858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007763356,"about_ca_topic_score_gemma":0.006374361,"domain_scores_codex":[0.9935456,0.003828658,0.000196613,0.001569565,0.0005042316,0.0003553464],"domain_scores_gemma":[0.9873361,0.007261105,0.001748346,0.002031331,0.0006522012,0.00097101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009994807,0.00008493313,0.9659662,0.0001007447,0.002243965,0.0008716912,0.0005986416,0.003149741,0.001527389,0.004346586,0.0004100052,0.01970048],"study_design_scores_gemma":[0.00006781906,0.0004109656,0.9397141,0.000140675,0.001908064,0.001995049,0.0005172224,0.01642909,0.0006062174,0.03645085,0.001675767,0.00008418834],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556262,0.008513703,0.02584538,0.003487216,0.0001626057,0.00005882188,0.000405337,0.0002841817,0.005616588],"genre_scores_gemma":[0.9934702,0.001186956,0.004078128,0.0002282495,0.0001217227,0.00001781883,0.0001268094,0.00003569466,0.0007345438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008503154,"threshold_uncertainty_score":0.0449695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03624908908159084,"score_gpt":0.3460730878071137,"score_spread":0.3098239987255229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}