{"id":"W4399271346","doi":"10.1093/brain/awae176","title":"Towards cascading genetic risk in Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research, Development and Innovation Office; National Health and Medical Research Council; Medical Research Council; Medical Research Council Canada; Ministero della Salute; Alzheimer’s Research UK; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; ZonMw; Wolfson Foundation; British Heart Foundation; University College London; UK Research and Innovation; Brain Research UK; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Weston Brain Institute; Agence Nationale de la Recherche; Wellcome Trust; Alzheimer's Disease Neuroimaging Initiative; National Institute on Aging; Alzheimer's Association","keywords":"Hazard ratio; Neurodegeneration; Apolipoprotein E; Alzheimer's Disease Neuroimaging Initiative; Disease; Oncology; Alzheimer's disease; Biomarker; Internal medicine; Proportional hazards model; Cohort; Confidence interval; Medicine; Allele; Psychology; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001560716,0.0001390571,0.00016168,0.0002109584,0.00004490257,0.00004554854,0.00006219291,0.00004171431,0.0003460498],"category_scores_gemma":[0.0001566166,0.000111951,0.0001209445,0.0003103407,0.00005290667,0.00006867492,0.00004443522,0.000185873,0.0005675801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000086525,"about_ca_system_score_gemma":0.0004431593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003098323,"about_ca_topic_score_gemma":0.00002738807,"domain_scores_codex":[0.9987589,0.00007923158,0.0001634232,0.0003268327,0.0003119398,0.0003597474],"domain_scores_gemma":[0.9990595,0.00009640805,0.00001401495,0.0002486924,0.00002015348,0.0005612551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00103772,0.001105412,0.425809,0.0003928085,0.01271696,0.04254626,0.0008827745,0.00004103403,0.0001175983,0.001298797,0.03535394,0.4786977],"study_design_scores_gemma":[0.001911854,0.0002104452,0.9766061,0.0004465189,0.001358985,0.00006822919,0.00006939708,0.006753705,0.0001965257,0.002520019,0.009610889,0.0002473035],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8134342,0.1761493,0.00007002563,0.004749871,0.0001609708,0.0007578466,0.0001377595,0.0001890361,0.004350977],"genre_scores_gemma":[0.998521,0.0004789259,0.000289242,0.0002374279,0.0001686863,0.00007579602,0.0000450631,0.00003432088,0.0001495353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5507972,"threshold_uncertainty_score":0.7295284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03624908908159084,"score_gpt":0.3460730878071137,"score_spread":0.3098239987255229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}