{"id":"W4399275376","doi":"10.7759/cureus.61522","title":"Dexmedetomidine Inhibits Hippocampal Neuronal Damage Caused by Persistent Isoflurane-Induced Hypotension in Rat Model of Chronic Cerebral Hypoperfusion","year":2024,"lang":"en","type":"article","venue":"Cureus","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"South Okanagan General Hospital","funders":"","keywords":"Dexmedetomidine; Isoflurane; Cerebral hypoperfusion; Anesthesia; Medicine; Hippocampal formation; Perfusion; Neuronal damage; Cerebral blood flow; Cardiology; Ischemia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002618869,0.0002831432,0.0003352709,0.0002115414,0.0001308839,0.00007831476,0.0004369041,0.0001596403,0.0001108494],"category_scores_gemma":[0.000274437,0.0002466587,0.0001842456,0.0005704722,0.0001613662,0.000344986,0.0002239603,0.0005944995,0.00008181968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140572,"about_ca_system_score_gemma":0.0003169377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004965777,"about_ca_topic_score_gemma":0.00003907987,"domain_scores_codex":[0.9972027,0.0002746636,0.0004085708,0.0007918599,0.0007297123,0.0005925206],"domain_scores_gemma":[0.9990506,0.0002535762,0.00005757506,0.0004027218,0.00004487221,0.0001906403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009629862,0.000210126,0.0001031799,0.00009808708,0.000002833106,0.0001497338,0.0002391644,0.0009116881,0.9961064,0.0001514512,0.001044228,0.0008868391],"study_design_scores_gemma":[0.0003703809,0.0004798085,0.00006761098,0.00009460185,0.00001035681,0.00004186829,0.00002488169,0.2767706,0.7217407,0.00006132204,0.0001621282,0.0001758045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972748,0.0004983452,0.00002329935,0.0009737507,0.0002184774,0.000622624,0.00002215983,0.0001047605,0.0002618047],"genre_scores_gemma":[0.9985716,0.0002721904,0.00001165632,0.0003069569,0.00007001989,0.00003059244,0.000008289936,0.00005660879,0.0006720917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2758589,"threshold_uncertainty_score":0.9999986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06166977314567589,"score_gpt":0.2887572598761991,"score_spread":0.2270874867305232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}