{"id":"W4399275376","doi":"10.7759/cureus.61522","title":"Dexmedetomidine Inhibits Hippocampal Neuronal Damage Caused by Persistent Isoflurane-Induced Hypotension in Rat Model of Chronic Cerebral Hypoperfusion","year":2024,"lang":"en","type":"article","venue":"Cureus","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"South Okanagan General Hospital","funders":"","keywords":"Dexmedetomidine; Isoflurane; Cerebral hypoperfusion; Anesthesia; Medicine; Hippocampal formation; Perfusion; Neuronal damage; Cerebral blood flow; Cardiology; Ischemia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001089539,0.0003982315,0.0004804575,0.0002064244,0.0001382148,0.0001348341,0.0002517632,0.0002452607,0.0007076383],"category_scores_gemma":[0.0001055702,0.0000928988,0.0002529735,0.0001180891,0.0002090919,0.0002042859,0.0001900158,0.0007730022,0.00009833261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001933435,"about_ca_system_score_gemma":0.0002886659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008045573,"about_ca_topic_score_gemma":0.001923254,"domain_scores_codex":[0.9999385,0.000007128413,0.000007364576,0.00001071619,0.00001431689,0.00002198451],"domain_scores_gemma":[0.9998965,0.000005893105,0.00004317291,0.000009159665,0.00001172372,0.00003357157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004112172,0.001072291,0.001738968,0.0002910903,0.00005510587,0.0002692764,0.00006911706,0.0001579033,0.9793005,0.00008372486,0.0002429403,0.01260679],"study_design_scores_gemma":[0.0007645999,0.03199431,0.04809871,0.00008175979,0.0002598851,0.0009201118,0.0003049503,0.001845666,0.9098048,0.0001854741,0.005709207,0.00003050852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995954,0.002745589,0.0006114217,0.0001016566,0.00005232446,0.00003124623,0.0001283811,0.00004329357,0.0003320866],"genre_scores_gemma":[0.99378,0.003595655,0.001141871,0.0001112775,0.00004352596,0.00008728523,0.0003265285,0.000005270729,0.0009086842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008045573,"threshold_uncertainty_score":0.002367258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06166977314567589,"score_gpt":0.2887572598761991,"score_spread":0.2270874867305232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}