{"id":"W4399276146","doi":"10.1101/2024.05.29.596269","title":"Structure-specific variation in per- and polyfluoroalkyl substances toxicity among genetically diverse <i>Caenorhabditis elegans</i> strains","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; York University; Johns Hopkins University","keywords":"Caenorhabditis elegans; Toxicity; Biology; Genetic variation; Genetics; Variation (astronomy); Toxicology; Chemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002792754,0.0003490456,0.0002024834,0.0008802871,0.0002325919,0.0003133905,0.0004052067,0.0003511722,0.0008153244],"category_scores_gemma":[0.0003574234,0.0002638595,0.0003175412,0.0002680268,0.0002862661,0.0001600694,0.0003566629,0.0004176501,0.0001570426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004239759,"about_ca_system_score_gemma":0.0001680412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0039727,"about_ca_topic_score_gemma":0.006563826,"domain_scores_codex":[0.9995847,0.00004247388,0.00005918345,0.0001274981,0.0001244325,0.00006169277],"domain_scores_gemma":[0.9994761,0.0001037997,0.0001700127,0.00006103966,0.0001033165,0.00008576294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001033367,0.00002740828,0.002787346,0.00001229183,0.00001481616,0.00002299047,0.00001888896,0.00006220804,0.9963968,0.00002067128,0.00001609075,0.0005171454],"study_design_scores_gemma":[0.00002839908,0.001296041,0.3468543,0.00001913742,0.0001313738,0.0006004446,0.0002267458,0.001382179,0.6480357,0.00005955199,0.001328939,0.00003709202],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982669,0.00008276135,0.0005436498,0.00001179748,0.000002870103,0.00001868794,0.0006164729,0.00001809375,0.000438689],"genre_scores_gemma":[0.996753,0.000087577,0.001306804,0.00002997942,0.000001657962,0.00003515303,0.001170965,0.00002252688,0.0005922006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0039727,"threshold_uncertainty_score":0.007899165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071408030810267,"score_gpt":0.214723578249684,"score_spread":0.2040094979415814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}