{"id":"W4399282528","doi":"10.21203/rs.3.rs-4396276/v1","title":"Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Ternary operation; Substrate (aquarium); Crystal (programming language); Materials science; Crystallography; Computer science; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002820981,0.0005273615,0.0004730298,0.0003165546,0.0006514632,0.001102936,0.000525019,0.000597781,0.004043481],"category_scores_gemma":[0.0005230769,0.0003730086,0.0002615773,0.0005290325,0.0001915127,0.0007015434,0.0003628036,0.001432121,0.0008643121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001590223,"about_ca_system_score_gemma":0.0004739643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003390922,"about_ca_topic_score_gemma":0.003949333,"domain_scores_codex":[0.9998773,0.00001027696,0.00001162229,0.00003111574,0.00004378274,0.00002584692],"domain_scores_gemma":[0.9998747,0.00003175799,0.00002602499,0.00001364056,0.00002535975,0.00002852834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002414361,0.0005127394,0.008635842,0.001139362,0.0003014636,0.001262691,0.0008595446,0.006434439,0.9037668,0.01833336,0.02579604,0.03054337],"study_design_scores_gemma":[0.000230439,0.0000909239,0.01088338,0.0000653903,0.0001444207,0.0009856537,0.0003759424,0.03925046,0.9008842,0.002334663,0.04466241,0.00009213291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969258,0.007071438,0.009556484,0.001085743,0.0001651741,0.00003297793,0.004065751,0.0005571988,0.008207284],"genre_scores_gemma":[0.9723585,0.002027019,0.01238873,0.0002009598,0.00001887724,0.00003533039,0.007241741,0.0001366741,0.005592119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004043481,"threshold_uncertainty_score":0.0135268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04363373516899011,"score_gpt":0.3579965805083571,"score_spread":0.314362845339367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}