{"id":"W4399284751","doi":"10.1016/j.omtn.2024.102234","title":"CircHTT(2,3,4,5,6) — co-evolving with the HTT CAG-repeat tract — modulates Huntington's disease phenotypes","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Real-time simulation and control systems","field":"Engineering","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; HORIZON EUROPE Framework Programme; Università degli Studi di Trento; Horizon 2020 Framework Programme; European Huntington's Disease Network; Hereditary Disease Foundation; Huntington Society of Canada; Cancer Prevention and Research Institute of Texas; European Molecular Biology Organization; European Regional Development Fund; European Commission; Pfizer; National Institutes of Health","keywords":"Huntington's disease; Polyglutamine tract; Phenotype; Disease; Biology; Genetics; Neuroscience; Huntingtin; Medicine; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007237702,0.0001767836,0.0001490853,0.0001005137,0.00008730963,0.0001510679,0.00009111743,0.0001746992,0.000756613],"category_scores_gemma":[0.00007441219,0.00005460834,0.0001200689,0.00006613673,0.0001384426,0.00006274663,0.00007865825,0.0002637136,0.0001574263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229533,"about_ca_system_score_gemma":0.00007786078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003027545,"about_ca_topic_score_gemma":0.0006069024,"domain_scores_codex":[0.9999442,0.00001145305,0.000005490683,0.00001556855,0.00001146086,0.00001188643],"domain_scores_gemma":[0.9999257,0.00001060888,0.00002437864,0.000004852288,0.00000498138,0.00002931651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006564898,0.00001202021,0.0001412646,0.000007080116,0.000001836382,0.00003884346,0.000004160844,0.00001461737,0.9992639,0.00002053948,0.0000126183,0.0004174943],"study_design_scores_gemma":[0.00002323456,0.0005889506,0.01727094,0.000004287801,0.00002814266,0.0003735538,0.00002288168,0.00129145,0.9784135,0.00004040515,0.00193669,0.000006025872],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983322,0.0005144246,0.0005461044,0.00003054562,0.00002356211,0.000009305668,0.000120539,0.00003257229,0.0003907021],"genre_scores_gemma":[0.9976553,0.0002598567,0.0006548151,0.00003493386,0.00001098165,0.000009171369,0.0001849833,0.00001738458,0.001172694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000756613,"threshold_uncertainty_score":0.002531171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005476684548015145,"score_gpt":0.2112992591748138,"score_spread":0.2058225746267986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}