{"id":"W4399290385","doi":"10.1101/2024.05.30.596758","title":"THE DUAL-SPECIFICITY KINASE DYRK1A INTERACTS WITH THE HEPATITIS B VIRUS GENOME AND REGULATES THE PRODUCTION OF VIRAL RNA","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Virology; RNA; Genome; Hepatitis B virus; Dual (grammatical number); DYRK1A; Biology; Virus; Kinase; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001359121,0.0004814677,0.0003297275,0.0002635774,0.0002313873,0.0003845031,0.0002344463,0.0002272162,0.001035583],"category_scores_gemma":[0.0001224428,0.0001933794,0.0002289904,0.0001390119,0.0002961587,0.0002487098,0.0002669043,0.000445319,0.0005959169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005363643,"about_ca_system_score_gemma":0.0001835119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002110579,"about_ca_topic_score_gemma":0.0003270242,"domain_scores_codex":[0.9998149,0.00003078652,0.00001303275,0.00006149291,0.0000435865,0.00003623946],"domain_scores_gemma":[0.9999322,0.000009203844,0.00002603875,0.00000587761,0.000006881656,0.00001987513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001242241,0.00001893836,0.0003315579,0.00005932714,0.000006333202,0.00004466663,0.000005776172,0.0001011517,0.9978548,0.0001277466,0.00006218764,0.001263336],"study_design_scores_gemma":[0.00003123844,0.0002242115,0.005347665,0.00000775642,0.00002359368,0.0006697813,0.00001968336,0.002336815,0.9877656,0.00007269593,0.003493451,0.000007636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802244,0.01167279,0.004507632,0.0002174504,0.00006507098,0.00003782952,0.0004124647,0.0001205915,0.002741813],"genre_scores_gemma":[0.9934694,0.002095933,0.001610498,0.00004674993,0.00002180571,0.00003792386,0.0003504131,0.00001893918,0.002348444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001035583,"threshold_uncertainty_score":0.003891647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270677470150273,"score_gpt":0.2235341106619291,"score_spread":0.2108273359604264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}