{"id":"W4399292593","doi":"10.1021/acs.molpharmaceut.4c00128","title":"Solid Lipid Nanoparticles for Pulmonary Delivery of Biopharmaceuticals: A Review of Opportunities, Challenges, and Delivery Applications","year":2024,"lang":"en","type":"review","venue":"Molecular Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Solid lipid nanoparticle; Biopharmaceutical; Nanocarriers; Nanotechnology; Drug delivery; Medicine; Computational biology; Pharmacology; Biotechnology; Drug; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006622843,0.0005078064,0.001984982,0.0003861542,0.00005026751,0.00001010892,0.0002074619,0.0003086537,0.00004006559],"category_scores_gemma":[0.0000478716,0.000423983,0.0007966744,0.0003101637,0.0002977583,0.00005129658,0.0001885506,0.000429603,0.00001670349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007479234,"about_ca_system_score_gemma":0.0007747691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.142336e-7,"about_ca_topic_score_gemma":1.242654e-7,"domain_scores_codex":[0.9971003,0.0002210854,0.001423151,0.0005202751,0.0004011547,0.0003340196],"domain_scores_gemma":[0.9979783,0.0001935221,0.0005169264,0.0005110269,0.000486101,0.0003141173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002102695,0.0001753674,5.352847e-8,0.3808222,0.0005430933,0.00007997105,0.0000197062,1.552421e-7,0.001988028,0.0004409218,0.0002360824,0.6156734],"study_design_scores_gemma":[0.0003366813,0.00008450506,4.674952e-8,0.07539354,0.01230136,0.0002447754,0.00003765243,0.000174257,0.004479359,0.00001352961,0.9066252,0.0003091499],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002245212,0.9948894,0.00006484828,0.0002919578,0.0001611468,0.003465392,0.0004165692,0.00006173577,0.0006264909],"genre_scores_gemma":[0.00009733268,0.9970803,0.0003604023,0.001168498,0.0001687554,0.0005924649,0.0002529861,0.0001218546,0.0001574301],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9063891,"threshold_uncertainty_score":0.9998212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2302574933272619,"score_gpt":0.4442683697438489,"score_spread":0.2140108764165869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}