{"id":"W4399292593","doi":"10.1021/acs.molpharmaceut.4c00128","title":"Solid Lipid Nanoparticles for Pulmonary Delivery of Biopharmaceuticals: A Review of Opportunities, Challenges, and Delivery Applications","year":2024,"lang":"en","type":"review","venue":"Molecular Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Solid lipid nanoparticle; Biopharmaceutical; Nanocarriers; Nanotechnology; Drug delivery; Medicine; Computational biology; Pharmacology; Biotechnology; Drug; Biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003592364,0.0006704716,0.0008478093,0.001955263,0.0002441679,0.0007128369,0.0004370402,0.0007516229,0.002589622],"category_scores_gemma":[0.0002670542,0.0003313588,0.0004935737,0.001750691,0.0002431978,0.000915742,0.0003862644,0.001101308,0.001415128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003958981,"about_ca_system_score_gemma":0.0007413827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008321453,"about_ca_topic_score_gemma":0.001330914,"domain_scores_codex":[0.9998693,0.00001784147,0.00001736177,0.0000216464,0.00006007662,0.00001361343],"domain_scores_gemma":[0.9998871,0.0000513564,0.00002000445,0.000003429324,0.00002815715,0.000009891255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006448141,0.0001737818,0.00014583,0.03496926,0.00008878481,0.0002895565,0.0001229339,0.001012593,0.01393842,0.0083197,0.02469905,0.9161758],"study_design_scores_gemma":[0.00001525463,0.0001923477,0.0006332637,0.003055969,0.00008804985,0.001148181,0.00006056416,0.0002858529,0.002137281,0.001627319,0.9907315,0.00002435157],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003196013,0.9975434,0.00033597,0.000139786,0.0001157527,0.000009188181,0.00001947378,0.00001023617,0.001506526],"genre_scores_gemma":[0.001044116,0.9974941,0.0004095683,0.00008726372,0.00007866699,0.00001245822,0.00002328319,0.000001893086,0.0008486266],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002589622,"threshold_uncertainty_score":0.008663118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2302574933272619,"score_gpt":0.4442683697438489,"score_spread":0.2140108764165869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}