{"id":"W4399295358","doi":"10.1002/mds.29866","title":"Magnetic Resonance Imaging Measures to Track Atrophy Progression in Progressive Supranuclear Palsy in Clinical Trials","year":2024,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIH Clinical Center; University of Chicago Medicine; Newcastle upon Tyne Hospitals NHS Foundation Trust; University of California, San Francisco; Deutsches Zentrum für Neurodegenerative Erkrankungen; Universität Rostock; Medical Research Council; Centre Hospitalier Universitaire de Bordeaux; Servier; Eli Lilly and Company; Ludwig-Maximilians-Universität München; RWTH Aachen University; Humboldt-Universität zu Berlin; H. Lundbeck A/S; Eberhard Karls Universität Tübingen; Universidad de Navarra; Eisai; University of Toronto; University of Pennsylvania; Volkswagen Foundation; Technische Universität Dresden; Korea University; Deutsche Forschungsgemeinschaft; University of Cambridge; Johns Hopkins University; GHR Foundation; Ochsner Health; Indiana University Health; National Institutes of Health; Regeneron Pharmaceuticals; Rush University; University of South Florida; Pennsylvania State University; University of South Carolina; Massachusetts General Hospital; University of Minnesota; University of Ottawa; University of Chicago; Morsani College of Medicine; Korea University Guro Hospital; Bristol-Myers Squibb; Teva Pharmaceutical Industries; Pfizer; Biogen; Rheinische Friedrich-Wilhelms-Universität Bonn; Alzheimer's Association; Alzheimer's Disease Neuroimaging Initiative; Sanofi; Bayer Vital","keywords":"Progressive supranuclear palsy; Magnetic resonance imaging; Atrophy; Cohort; Medicine; Nuclear medicine; Psychology; Internal medicine; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001761297,0.000265788,0.0006215234,0.0003343676,0.00004125724,0.00007325644,0.0001100809,0.00008019942,0.0002254476],"category_scores_gemma":[0.000414149,0.0002072642,0.0002504828,0.00049802,0.00005547555,0.0001035763,0.00006159376,0.0002510354,0.00009098367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722564,"about_ca_system_score_gemma":0.0001231401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009456821,"about_ca_topic_score_gemma":0.0001506291,"domain_scores_codex":[0.99698,0.0004162494,0.0009266145,0.0007032678,0.0005086841,0.0004652228],"domain_scores_gemma":[0.9992408,0.0001284882,0.00007911262,0.0002906192,0.00003052831,0.000230471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001064436,0.001260299,0.1952812,0.0001126432,0.00003408134,0.0007548822,0.0003294374,0.000006919709,0.0003170776,0.0002336793,0.001495615,0.7991098],"study_design_scores_gemma":[0.01116824,0.001843602,0.8909225,0.003393169,0.0002257878,0.00000173357,0.0006631291,0.003030356,0.0004195536,0.009687031,0.07814753,0.0004973345],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9216685,0.06643853,0.00008110474,0.006776669,0.0004775161,0.003535349,0.00003615559,0.0001482474,0.0008379192],"genre_scores_gemma":[0.9949791,0.001073198,0.0009822717,0.002066504,0.00008996497,0.0005656898,0.00002226068,0.00005455159,0.0001664689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7986124,"threshold_uncertainty_score":0.8451989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04035962101401377,"score_gpt":0.3846145610797248,"score_spread":0.344254940065711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}