{"id":"W4399302312","doi":"10.3390/ijms25116134","title":"In Vitro Cell Culture Model for Osteoclast Activation during Estrogen Withdrawal","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Osteoclast; Bone resorption; Estrogen; Podosome; Chemistry; Bone remodeling; Internal medicine; Endocrinology; Osteoporosis; Resorption; Ovariectomized rat; Cell biology; Population; Bone cell; RHOA; In vitro; Cell; Biology; Medicine; Signal transduction; Cytoskeleton; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006792345,0.0006014775,0.000993,0.0005937135,0.0007444889,0.0006261464,0.0006871095,0.0007833238,0.002376058],"category_scores_gemma":[0.0002037595,0.0003755615,0.001031825,0.000874047,0.0003400822,0.0003216339,0.0005652878,0.001963921,0.001598071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004518433,"about_ca_system_score_gemma":0.0005999245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002127685,"about_ca_topic_score_gemma":0.004427806,"domain_scores_codex":[0.9988292,0.0001385774,0.0001951551,0.0002899984,0.0003863529,0.0001606623],"domain_scores_gemma":[0.9995798,0.00008011545,0.0000627425,0.00008635737,0.0001202823,0.00007069725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004739513,0.0004706731,0.001309205,0.0003026749,0.0000325757,0.0005791084,0.0002003241,0.0003340654,0.9921628,0.0007543683,0.0005286708,0.002851681],"study_design_scores_gemma":[0.0001794149,0.003103818,0.01086674,0.00007754865,0.0002858183,0.002478895,0.0002937351,0.005558757,0.9403563,0.0006850484,0.03604392,0.00006989339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8647636,0.01867245,0.08461329,0.0008736342,0.001350148,0.001331902,0.007075388,0.0006753558,0.02064432],"genre_scores_gemma":[0.9028274,0.0111843,0.05554479,0.0006737377,0.0002516094,0.002739421,0.008096322,0.00008499819,0.01859743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002376058,"threshold_uncertainty_score":0.007948697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007241771922031535,"score_gpt":0.2715717401236882,"score_spread":0.2643299682016567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}