{"id":"W4399317454","doi":"10.1159/000539541","title":"Pharmacokinetic-Guided Hydroxyurea to Reduce Transfusions in Ugandan Children with Sickle Cell Anemia: Study Design of the Alternative Dosing And Prevention of Transfusions Trial","year":2024,"lang":"en","type":"article","venue":"Acta Haematologica","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fogarty International Center; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute","keywords":"Dosing; Medicine; Anemia; Intensive care medicine; Pharmacokinetics; Clinical trial; Hydroxycarbamide; Sickle cell anemia; Blood transfusion; Pharmacology; Internal medicine; Chemotherapy; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004266642,0.001305679,0.001652214,0.0002858358,0.0005737271,0.001021028,0.0007263962,0.001251786,0.00412616],"category_scores_gemma":[0.00479088,0.0006627381,0.002014315,0.000351234,0.001066062,0.0007359203,0.0008275085,0.00245376,0.0005084758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006780641,"about_ca_system_score_gemma":0.00192052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007588862,"about_ca_topic_score_gemma":0.001039869,"domain_scores_codex":[0.9981927,0.00122034,0.0001100372,0.0002068175,0.00009124915,0.0001787413],"domain_scores_gemma":[0.9978581,0.0006534015,0.0006182964,0.0002500112,0.000184986,0.0004352028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9293203,0.01938452,0.01799368,0.001127001,0.002540104,0.0001476038,0.0003590782,0.001547871,0.001774288,0.0005486705,0.001340203,0.02391656],"study_design_scores_gemma":[0.6466674,0.3195544,0.02433427,0.0002409386,0.002133668,0.0002135644,0.0001787253,0.001588877,0.0009549428,0.000828149,0.003259737,0.00004525914],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.987326,0.001429538,0.0007226435,0.0004133328,0.0002093407,0.007417766,0.0007431342,0.00002663121,0.001711629],"genre_scores_gemma":[0.979153,0.0005622541,0.002209632,0.0005185535,0.0001566711,0.01569371,0.0004218988,0.000008815081,0.001275553],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.004266642,"threshold_uncertainty_score":0.02256441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704465809984711,"score_gpt":0.3045462288866054,"score_spread":0.2775015707867583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}