{"id":"W4399319803","doi":"10.1136/gutjnl-2024-332489","title":"Acute severe ulcerative colitis trials: the past, the present and the future","year":2024,"lang":"en","type":"review","venue":"Gut","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Samsung; Genentech; Norgine; Medac; Nordic Pharma Group; Sun Pharma; Celltrion; Boston Pharmaceuticals; Mylan; Novo Nordisk; Teva Pharmaceutical Industries; Gilead Sciences; Sanofi; Celgene; Biogen; GlaxoSmithKline; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Clinical trial; Ulcerative colitis; Intensive care medicine; Infliximab; Population; Randomized controlled trial; Colectomy; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008677942,0.000945897,0.004060259,0.001958446,0.0002654851,0.002054146,0.001475883,0.002171881,0.003428242],"category_scores_gemma":[0.01425893,0.0004170036,0.002141535,0.003240932,0.0005953852,0.001669511,0.0007012352,0.001931738,0.0006537327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001551292,"about_ca_system_score_gemma":0.004423799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409564,"about_ca_topic_score_gemma":0.003954845,"domain_scores_codex":[0.9964052,0.001992254,0.0006970382,0.000228599,0.0005381554,0.0001387463],"domain_scores_gemma":[0.9882997,0.009272845,0.001229954,0.0001400468,0.0008113718,0.0002460022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008504385,0.00005209616,0.0001882568,0.237213,0.001263717,0.0000728033,0.000118239,0.0002527374,0.0003633945,0.002558368,0.01581138,0.7412555],"study_design_scores_gemma":[0.001556401,0.001052196,0.00281987,0.3362185,0.00779882,0.0007612542,0.0002631479,0.0001659443,0.0003662636,0.004703021,0.644232,0.00006262775],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005094305,0.9994115,0.00002394578,0.0002672546,0.00008601359,0.00001067241,0.00001193906,0.000002367447,0.0001354149],"genre_scores_gemma":[0.0007609619,0.998323,0.0001612007,0.000485703,0.00009456258,0.00004335522,0.00002235146,0.000002244789,0.0001066594],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008677942,"threshold_uncertainty_score":0.04589391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02369999587908996,"score_gpt":0.3287816429463793,"score_spread":0.3050816470672894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}