{"id":"W4399319803","doi":"10.1136/gutjnl-2024-332489","title":"Acute severe ulcerative colitis trials: the past, the present and the future","year":2024,"lang":"en","type":"review","venue":"Gut","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Samsung; Genentech; Norgine; Medac; Nordic Pharma Group; Sun Pharma; Celltrion; Boston Pharmaceuticals; Mylan; Novo Nordisk; Teva Pharmaceutical Industries; Gilead Sciences; Sanofi; Celgene; Biogen; GlaxoSmithKline; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Clinical trial; Ulcerative colitis; Intensive care medicine; Infliximab; Population; Randomized controlled trial; Colectomy; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001163557,0.0003572392,0.0006543116,0.00001582539,0.0002498651,0.0001861474,0.0005259519,0.0002706543,0.00003126595],"category_scores_gemma":[0.00008381286,0.0001226265,0.0006614111,0.00007317593,0.000338826,0.000002003703,0.000391834,0.0003792582,0.00006320674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001745624,"about_ca_system_score_gemma":0.0002966897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003205681,"about_ca_topic_score_gemma":0.00002882751,"domain_scores_codex":[0.9970706,0.001744837,0.0004117872,0.0003812221,0.0001707089,0.0002208443],"domain_scores_gemma":[0.9987169,0.0001734344,0.0002279819,0.0007681337,0.00005582218,0.0000577455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004326611,0.00001400721,8.059514e-7,0.002853185,0.003288361,0.0001381938,0.0003097699,8.958031e-7,0.000001362903,0.00320499,0.5605256,0.4292302],"study_design_scores_gemma":[0.0003706748,0.00001609205,0.00002957167,0.0003639992,0.003007294,0.0001113778,0.0001089876,0.000002811626,8.12276e-7,0.0002199752,0.9955952,0.0001732109],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003645368,0.9927188,0.000004658739,0.002257592,0.0006912093,0.00206117,0.0006158882,0.0000113852,0.001602818],"genre_scores_gemma":[0.00003592639,0.9856218,0.0000048856,0.000360763,0.00682199,0.0006976775,0.0001976496,0.00004273962,0.006216624],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4350696,"threshold_uncertainty_score":0.5000563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02369999587908996,"score_gpt":0.3287816429463793,"score_spread":0.3050816470672894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}