{"id":"W4399319966","doi":"10.1200/jco.2024.42.16_suppl.tps1127","title":"Open-label, randomized, multicenter, phase 3, ELAINE 3 study of the efficacy and safety of lasofoxifene plus abemaciclib for treating ER+/HER2-, locally advanced or metastatic breast cancer with an <i>ESR1</i> mutation.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Metastatic breast cancer; Oncology; Breast cancer; Internal medicine; Open label; Randomized controlled trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003566376,0.0002516393,0.00297802,0.00010735,0.00007576405,0.00002040059,0.0003348021,0.0001025684,0.00006382648],"category_scores_gemma":[0.002169215,0.0001222496,0.0002034388,0.0003148382,0.0005877096,0.0003666549,0.00009834825,0.000542061,2.484756e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001752715,"about_ca_system_score_gemma":0.002060845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007742294,"about_ca_topic_score_gemma":0.0004241325,"domain_scores_codex":[0.9950483,0.0009065743,0.00304318,0.0003376653,0.0004230183,0.0002412232],"domain_scores_gemma":[0.9873036,0.008810398,0.002464256,0.0002828145,0.0008931294,0.0002458369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6101314,0.006983164,0.0002336771,0.0002400449,0.002013979,0.0001480827,0.0009147819,0.0009500421,0.0005012355,0.00003241767,0.00001286495,0.3778383],"study_design_scores_gemma":[0.9182295,0.0610818,0.00238362,0.001927277,0.004193336,0.0009704955,0.002555076,0.006958165,0.00027195,0.000111759,0.001150801,0.0001662312],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833586,0.002145295,0.00702011,0.003012331,0.0005595067,0.003754144,0.0001001647,0.00001369269,0.00003618683],"genre_scores_gemma":[0.9703441,0.0005843933,0.0278647,0.0005791471,0.0002977188,0.00011797,0.000003827727,0.00005151045,0.0001566463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.377672,"threshold_uncertainty_score":0.4985194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09312446749221592,"score_gpt":0.5052449030153938,"score_spread":0.4121204355231779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}