{"id":"W4399319966","doi":"10.1200/jco.2024.42.16_suppl.tps1127","title":"Open-label, randomized, multicenter, phase 3, ELAINE 3 study of the efficacy and safety of lasofoxifene plus abemaciclib for treating ER+/HER2-, locally advanced or metastatic breast cancer with an <i>ESR1</i> mutation.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Metastatic breast cancer; Oncology; Breast cancer; Internal medicine; Open label; Randomized controlled trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00204154,0.001915984,0.002705549,0.000421804,0.0004864861,0.001337392,0.00114078,0.001749249,0.005478529],"category_scores_gemma":[0.001564529,0.0008279095,0.001418269,0.000418494,0.001311853,0.00124364,0.0004092355,0.003947855,0.001403386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009148198,"about_ca_system_score_gemma":0.001553568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001192631,"about_ca_topic_score_gemma":0.003702606,"domain_scores_codex":[0.9993355,0.0003351317,0.00002400579,0.0001214564,0.00007931801,0.000104565],"domain_scores_gemma":[0.9988045,0.0002603427,0.0003114705,0.0001037562,0.00008742027,0.000432619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9524662,0.02289117,0.0007216646,0.000283822,0.0006245986,0.00006788161,0.00008245862,0.0005310489,0.007955943,0.0001228718,0.001407551,0.01284477],"study_design_scores_gemma":[0.8889066,0.106845,0.001905375,0.00001219483,0.0001660021,0.00005864598,0.00002285558,0.0005391994,0.0006530643,0.0001306911,0.0007426313,0.00001762626],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869437,0.001658036,0.001031441,0.0005586896,0.0003263435,0.004740221,0.001984224,0.0002383231,0.002518957],"genre_scores_gemma":[0.9780226,0.001653878,0.002870063,0.002003697,0.0005232973,0.00639203,0.003239701,0.00008467453,0.005210166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005478529,"threshold_uncertainty_score":0.01832753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09312446749221592,"score_gpt":0.5052449030153938,"score_spread":0.4121204355231779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}