{"id":"W4399323365","doi":"10.3390/ijms25116194","title":"CaMKIV-Mediated Phosphorylation Inactivates Freud-1/CC2D1A Repression for Calcium-Dependent 5-HT1A Receptor Gene Induction","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"CAMK; Phosphorylation; Biology; CREB; Repressor; Protein kinase A; 5-HT1A receptor; Receptor; Cell biology; Gene; Gene expression; 5-HT receptor; Transcription factor; Biochemistry; Serotonin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008704453,0.0003859365,0.0003234723,0.0001990686,0.0002017913,0.0002701542,0.0003786311,0.0002338215,0.002282842],"category_scores_gemma":[0.0001219734,0.000139873,0.0003112303,0.0001533647,0.0002362991,0.0001409331,0.0002052054,0.0004925879,0.0004563587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005953137,"about_ca_system_score_gemma":0.0003207261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002010714,"about_ca_topic_score_gemma":0.002864655,"domain_scores_codex":[0.9998751,0.00001395898,0.00001281454,0.00002680865,0.00002576843,0.00004554629],"domain_scores_gemma":[0.9999362,0.00001173504,0.00001681421,0.000009574083,0.000005759411,0.00001994866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000121984,0.00003006263,0.00007990337,0.00003854747,0.000004491118,0.0000221197,0.000009912184,0.00002815866,0.9988067,0.0001187631,0.0000547174,0.0006845943],"study_design_scores_gemma":[0.00005009118,0.0001714352,0.00459829,0.000009559313,0.00001386113,0.0001681847,0.00001421423,0.00114528,0.9893212,0.00004160217,0.004460617,0.000005639602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932787,0.00292751,0.001084452,0.0001168945,0.00008396427,0.00003716598,0.0004830557,0.000070533,0.001917683],"genre_scores_gemma":[0.9943371,0.0009000919,0.0009685166,0.000038981,0.00001659575,0.00004820761,0.001018069,0.00001767084,0.002654717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002282842,"threshold_uncertainty_score":0.007636845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740211501690881,"score_gpt":0.2952557292903746,"score_spread":0.2778536142734658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}