{"id":"W4399323727","doi":"10.1200/jco.2024.42.16_suppl.1055","title":"Impact of prior anticancer treatments on palbociclib (PAL) clinical outcomes in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer (ABC) in real-world settings.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Palbociclib; Medicine; Human Epidermal Growth Factor Receptor 2; Cancer; Oncology; Hormone receptor; Internal medicine; Breast cancer; Receptor; Cancer research; Epidermal growth factor receptor; Metastatic breast cancer; Gynecology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001707128,0.0005794117,0.003996423,0.000617087,0.00005600982,0.00001801434,0.0002974769,0.0004895655,0.0005024944],"category_scores_gemma":[0.001462763,0.0003625517,0.001034251,0.0007875634,0.0007298567,0.0005498753,0.00007642387,0.002342506,0.00001421078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002528584,"about_ca_system_score_gemma":0.002260054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008042983,"about_ca_topic_score_gemma":0.0006850158,"domain_scores_codex":[0.9919608,0.00106137,0.004699021,0.0007393958,0.0008452698,0.0006941712],"domain_scores_gemma":[0.9906196,0.004825883,0.002789942,0.0003473629,0.0008431961,0.0005739938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03587802,0.004774697,0.770357,0.00005348728,0.001905625,0.0001840763,0.0003752892,0.00003447064,0.0001354595,0.00002792224,0.0002240114,0.18605],"study_design_scores_gemma":[0.0321239,0.02611315,0.9389545,0.001578845,0.0002964665,0.00001693989,0.00009097455,0.00001238135,0.00008738942,0.0001143948,0.0002991201,0.0003119482],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934382,0.0002896661,0.00001155227,0.003532835,0.0009815068,0.0009931267,0.0004054555,0.00003243474,0.0003152541],"genre_scores_gemma":[0.9938991,0.00171394,0.002620895,0.0006714332,0.0006905657,0.00004038583,0.00002340072,0.0001013444,0.0002389042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1857381,"threshold_uncertainty_score":0.9999591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04992408298050553,"score_gpt":0.4670128968005136,"score_spread":0.4170888138200081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}