{"id":"W4399324177","doi":"10.1126/scisignal.ade8041","title":"Growth factor–dependent phosphorylation of Gα <sub>i</sub> shapes canonical signaling by G protein–coupled receptors","year":2024,"lang":"en","type":"article","venue":"Science Signaling","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; National Cancer Institute; National Institutes of Health; Université de Montréal; National Institute of Allergy and Infectious Diseases; Augusta University; National Institute of General Medical Sciences; University of South Carolina; American Association of Immunologists","keywords":"G protein-coupled receptor; Phosphorylation; Signal transduction; Tyrosine phosphorylation; G protein; Biology; Cell biology; Protein phosphorylation; Receptor; Biochemistry; Chemistry; Protein kinase A","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001290616,0.0002425297,0.0002443423,0.0002142185,0.0001704833,0.0001541316,0.0004203335,0.000178953,0.0001382143],"category_scores_gemma":[0.0002092208,0.0002268694,0.0001293555,0.0007079269,0.0002246814,0.00004706856,0.0001241103,0.0002238317,0.00000932578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009843328,"about_ca_system_score_gemma":0.0005060864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008027818,"about_ca_topic_score_gemma":0.0000138506,"domain_scores_codex":[0.9974185,0.00006553582,0.0005196219,0.0008071074,0.0006640013,0.0005252031],"domain_scores_gemma":[0.9993166,0.00003924285,0.0001275596,0.0001797026,0.0001871932,0.0001496498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002935125,0.00003273578,0.0001583023,0.00005467987,0.00001568458,0.000004092397,0.0001813514,0.001079901,0.9960344,0.0002890847,0.00001753038,0.002102864],"study_design_scores_gemma":[0.0001937053,0.0001792793,0.00002644325,0.000214506,0.000009852133,0.000003691337,0.000176341,0.005100069,0.9933578,0.0003830158,0.00007904236,0.0002762661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984517,0.001663873,0.01291512,0.00004298827,0.0003817717,0.0003446767,0.00001550294,0.0000343298,0.00008477434],"genre_scores_gemma":[0.998852,0.00007693678,0.0007669312,0.00002984486,0.0001385144,0.00003229629,0.00002426625,0.00003312416,0.00004613781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01433499,"threshold_uncertainty_score":0.9251466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008897355700794574,"score_gpt":0.2363841105079764,"score_spread":0.2274867548071818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}