{"id":"W4399326604","doi":"10.1158/0008-5472.can-23-0519","title":"Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; McGill University Health Centre","funders":"Cancer Council South Australia; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Fondazione Umberto Veronesi; Dana-Farber Cancer Institute; Government of South Australia; Foundation Medicine; McGill University; McGill University Health Centre; World Cancer Research Fund International; World Cancer Research Fund; Harvard T.H. Chan School of Public Health; Brown University; Università degli Studi di Milano; National Cancer Institute; Brigham and Women's Hospital; Università degli Studi di Pavia; U.S. Department of Defense","keywords":"Prostate cancer; Tumor microenvironment; Cancer research; Cancer; Glycolysis; Biology; Lactate dehydrogenase; Anaerobic glycolysis; Lactate dehydrogenase A; Tumor progression; Internal medicine; Cancer cell; Endocrinology; Medicine; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000440773,0.0001491407,0.0001587637,0.0001284183,0.00009884901,0.0001192324,0.00009688258,0.00005838286,0.00004219723],"category_scores_gemma":[0.00002323795,0.0001378696,0.00002333267,0.000229122,0.00009397133,0.00001513918,0.0002228072,0.0002193265,0.000008316169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001121436,"about_ca_system_score_gemma":0.0001898028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001352691,"about_ca_topic_score_gemma":0.001362152,"domain_scores_codex":[0.998468,0.0000829717,0.000182671,0.00061628,0.0002039022,0.0004461301],"domain_scores_gemma":[0.9995446,0.0000108173,0.00001757575,0.0001975608,0.00007158688,0.0001578625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004504634,0.00001527405,0.0005406403,0.0001441319,0.00002881952,0.000007085232,0.0004685284,0.00161048,0.9645572,0.0000132769,0.002233563,0.02993052],"study_design_scores_gemma":[0.001464381,0.0004696834,0.008418507,0.0005227138,0.00003529855,0.00001526599,0.0001558308,0.003515365,0.4671029,0.0002032932,0.5175847,0.0005120296],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458886,0.05188699,0.00002377126,0.001071416,0.000318203,0.0006822223,0.00009731011,0.000009942852,0.00002149488],"genre_scores_gemma":[0.9693103,0.02711424,0.0001343499,0.0001695479,0.0007744285,0.0004061799,0.00003167272,0.00004098413,0.002018298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5153512,"threshold_uncertainty_score":0.562216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04075172549784481,"score_gpt":0.3672430065491485,"score_spread":0.3264912810513038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}