{"id":"W4399326604","doi":"10.1158/0008-5472.can-23-0519","title":"Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; McGill University Health Centre","funders":"Cancer Council South Australia; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Fondazione Umberto Veronesi; Dana-Farber Cancer Institute; Government of South Australia; Foundation Medicine; McGill University; McGill University Health Centre; World Cancer Research Fund International; World Cancer Research Fund; Harvard T.H. Chan School of Public Health; Brown University; Università degli Studi di Milano; National Cancer Institute; Brigham and Women's Hospital; Università degli Studi di Pavia; U.S. Department of Defense","keywords":"Prostate cancer; Tumor microenvironment; Cancer research; Cancer; Glycolysis; Biology; Lactate dehydrogenase; Anaerobic glycolysis; Lactate dehydrogenase A; Tumor progression; Internal medicine; Cancer cell; Endocrinology; Medicine; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009678462,0.0002203033,0.0002285398,0.0001965165,0.00009228551,0.0002670063,0.0001000756,0.0001203885,0.0006360124],"category_scores_gemma":[0.00005662512,0.0001250801,0.0002555519,0.0001633533,0.0001589433,0.0001295511,0.0002788938,0.000460636,0.0001174323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001506556,"about_ca_system_score_gemma":0.0001983464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003282245,"about_ca_topic_score_gemma":0.0007708134,"domain_scores_codex":[0.9999269,0.00001455783,0.000004608202,0.00001381638,0.00001677392,0.0000232581],"domain_scores_gemma":[0.9999375,0.000004689489,0.00002040171,0.000008680645,0.000005068207,0.00002361997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005123755,0.00009532784,0.003380734,0.00006323787,0.00002205378,0.0001434404,0.00002598479,0.0001712636,0.9915554,0.0001405954,0.00008547642,0.00380412],"study_design_scores_gemma":[0.00008538466,0.002489335,0.1698197,0.00002483134,0.0001308893,0.001658838,0.000208038,0.003522185,0.8155206,0.0003720942,0.006138162,0.00003001514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966682,0.001202068,0.001305886,0.00007581252,0.00001298286,0.0000118295,0.0001758674,0.00005877297,0.0004886797],"genre_scores_gemma":[0.9980301,0.0005600798,0.0005313598,0.00003597574,0.000005112216,0.00001552796,0.0001298956,0.00000959768,0.0006822687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006360124,"threshold_uncertainty_score":0.002127647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04075172549784481,"score_gpt":0.3672430065491485,"score_spread":0.3264912810513038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}