{"id":"W4399331179","doi":"10.3389/fopht.2024.1373549","title":"Intensity-based optoretinography reveals sub-clinical deficits in cone function in retinitis pigmentosa","year":2024,"lang":"en","type":"article","venue":"Frontiers in Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Eye Institute; National Institutes of Health; Foundation Fighting Blindness","keywords":"Retinitis pigmentosa; Achromatopsia; Retinal; Retina; Ophthalmology; Optical coherence tomography; Scanning laser ophthalmoscopy; Retinal degeneration; Ophthalmoscopy; Biology; Medicine; Physics; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004215092,0.0003125121,0.0001901689,0.000828745,0.0002041617,0.0002874885,0.0001604359,0.0003324341,0.0008737997],"category_scores_gemma":[0.0006300023,0.0001818531,0.0001302684,0.0002410293,0.0003088924,0.0002127329,0.0002596556,0.0002127654,0.0001739442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000211845,"about_ca_system_score_gemma":0.0001040435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001613276,"about_ca_topic_score_gemma":0.002327188,"domain_scores_codex":[0.9998513,0.00002299646,0.00001961354,0.00004482011,0.00003927606,0.00002179447],"domain_scores_gemma":[0.999703,0.00004521243,0.0001242971,0.00003653308,0.00005078273,0.000040133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001058461,0.0001921872,0.7712638,0.00006535886,0.00009363644,0.003119098,0.0005336495,0.0003363505,0.2038747,0.00007439726,0.0001750365,0.01921333],"study_design_scores_gemma":[0.00001154941,0.0002573983,0.9869028,0.000008413861,0.00003379658,0.006023508,0.0001522214,0.0004618029,0.006009346,0.00003799533,0.00009664382,0.000004591403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995077,0.00006579004,0.0001890824,0.000007791476,6.181875e-7,0.000003812182,0.00002077501,0.00000892456,0.000195658],"genre_scores_gemma":[0.9994766,0.00004115102,0.0003344937,0.00001315928,0.000001466096,0.000003237954,0.00002446208,0.000001922039,0.0001035903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613276,"threshold_uncertainty_score":0.003207743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646379968978178,"score_gpt":0.2847066856628549,"score_spread":0.2682428859730731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}