{"id":"W4399331820","doi":"10.1016/j.bbrc.2024.150215","title":"An acidic pH environment converts necroptosis to apoptosis","year":2024,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Necroptosis; Programmed cell death; RIPK1; Cell biology; Apoptosis; Kinase; Extracellular; Intracellular; Biology; Caspase; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252349,0.0002255763,0.0001901312,0.0001481372,0.0001551376,0.0003534041,0.0001488463,0.000302317,0.002190456],"category_scores_gemma":[0.0001755021,0.0001626903,0.0001737314,0.00008476342,0.0002367675,0.0003670436,0.0002968965,0.0004652084,0.0003614717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002291999,"about_ca_system_score_gemma":0.0001615591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00020201,"about_ca_topic_score_gemma":0.000248606,"domain_scores_codex":[0.9998795,0.00001737079,0.00001020224,0.00001864789,0.00003168744,0.00004254231],"domain_scores_gemma":[0.9998924,0.00001935852,0.00002119827,0.00001562273,0.00001327274,0.0000382344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005685244,0.00002423674,0.0001864256,0.0000176189,0.000004524709,0.0001731042,0.000009691676,0.0000514498,0.9979277,0.0002106346,0.00004450932,0.0007815933],"study_design_scores_gemma":[0.00002565643,0.0002811629,0.002919188,0.000004579747,0.000005851199,0.0005864839,0.00004252162,0.0002863256,0.9941147,0.0002387808,0.001490157,0.000004685162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877524,0.001636914,0.005120987,0.0002749889,0.0001276862,0.00003617818,0.0003167497,0.0001444016,0.004589685],"genre_scores_gemma":[0.9960815,0.0004810384,0.001046162,0.0001053935,0.00002089894,0.00000975705,0.0002480127,0.00001626145,0.00199094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002190456,"threshold_uncertainty_score":0.007327735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04273256283794819,"score_gpt":0.3525367231280111,"score_spread":0.3098041602900629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}