{"id":"W4399339598","doi":"10.1212/wnl.0000000000209533","title":"Prevalence and Impact of Bypassing or Overriding Phase 2 Trials in Neurologic Drug Development","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Della Martin Foundation","keywords":"Drug development; Medicine; Drug; Clinical trial; Intensive care medicine; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.008720306,0.0001789182,0.001016525,0.0001803088,0.00002797979,0.00003015884,0.0001549893,0.0001489958,0.0003281328],"category_scores_gemma":[0.1359318,0.0001171403,0.0001198027,0.0002320163,0.0001567482,0.0000564693,0.0001293581,0.0004082223,0.000004740614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002108413,"about_ca_system_score_gemma":0.0001731915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001038345,"about_ca_topic_score_gemma":0.00000596578,"domain_scores_codex":[0.9943674,0.00326673,0.001463415,0.0004458652,0.0001650915,0.0002914571],"domain_scores_gemma":[0.8790007,0.1204622,0.0002473179,0.0001918029,0.0000234778,0.00007450367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.04099881,0.004064303,0.07122633,0.01308806,0.001047611,0.006520372,0.005300329,0.0001670919,0.04912394,0.09640931,0.006768881,0.705285],"study_design_scores_gemma":[0.006387907,0.006251114,0.03539127,0.0003798557,0.0003487011,0.0002447088,0.000007217312,0.008568445,0.003940889,0.9372518,0.0007122954,0.0005157809],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923351,0.0002257805,0.00583326,0.0003852937,0.0005672014,0.0004366708,0.0000295436,0.00006718446,0.000119989],"genre_scores_gemma":[0.9132026,0.00009455046,0.08631948,0.0001911545,0.0001022079,0.00003002373,3.149231e-7,0.00002567299,0.00003398504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8408425,"threshold_uncertainty_score":0.8713466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6486352195992298,"score_gpt":0.6254908834832205,"score_spread":0.0231443361160093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}