{"id":"W4399353743","doi":"10.1101/2024.06.04.597308","title":"Discovery and mechanistic characterization of a probiotic-origin 3β-OH-Δ <sup>5-6</sup> -cholesterol-5β-reductase directly converting cholesterol to coprostanol","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Coprostanol; Cholesterol; Dehydrogenase; Chemistry; Biochemistry; Enzyme; Sterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003489217,0.0008050583,0.0006746664,0.0001337608,0.0001103743,0.0003504353,0.0005115291,0.0008313601,0.00000784851],"category_scores_gemma":[0.0001959282,0.0008526589,0.0001828944,0.0002843745,0.0001573104,0.00002262695,0.001236894,0.000592818,0.00001337638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048551,"about_ca_system_score_gemma":0.0004108593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001386012,"about_ca_topic_score_gemma":6.931845e-7,"domain_scores_codex":[0.9965507,0.00008181236,0.0007972878,0.001648775,0.0003329082,0.000588502],"domain_scores_gemma":[0.997642,0.00001852687,0.0004455262,0.001239739,0.0003316093,0.0003225407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001386144,0.0001315167,0.0007793558,0.00254068,0.000238056,0.00002084734,0.0000300158,0.00002231055,0.9960152,0.00001786389,0.00005967462,0.000005867874],"study_design_scores_gemma":[0.0005197983,0.0001409277,0.001635694,0.001283704,0.0002146219,5.824717e-7,0.00001191194,0.0001727749,0.9944732,0.000002016753,0.0007063799,0.000838457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955052,0.0005472098,0.0006431993,0.0001412258,0.0004096287,0.0009038856,0.001727451,0.0001146038,0.000007605475],"genre_scores_gemma":[0.9979039,0.0001796377,0.0004708561,0.000251468,0.000702712,0.0002081674,0.00003530013,0.0001645966,0.00008336504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002398707,"threshold_uncertainty_score":0.9993924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007447783833597089,"score_gpt":0.2137672349755536,"score_spread":0.2063194511419565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}