{"id":"W4399353743","doi":"10.1101/2024.06.04.597308","title":"Discovery and mechanistic characterization of a probiotic-origin 3β-OH-Δ <sup>5-6</sup> -cholesterol-5β-reductase directly converting cholesterol to coprostanol","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Coprostanol; Cholesterol; Dehydrogenase; Chemistry; Biochemistry; Enzyme; Sterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003624921,0.0003649122,0.0003475863,0.000147982,0.0001732859,0.0006063603,0.0003325428,0.0004808165,0.001283935],"category_scores_gemma":[0.0003393315,0.0001220699,0.0004067786,0.0001815829,0.0002154464,0.0002188628,0.0003714155,0.0005477932,0.0009839119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002685609,"about_ca_system_score_gemma":0.0003678949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00067859,"about_ca_topic_score_gemma":0.0004267026,"domain_scores_codex":[0.9998419,0.00002803242,0.00001358748,0.00003112149,0.00005580486,0.00002947133],"domain_scores_gemma":[0.9999077,0.00001436713,0.00001952774,0.00001899666,0.00001850516,0.00002082237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001865371,0.00005824077,0.0009470464,0.0001185468,0.00002178468,0.0003209095,0.00002547806,0.0002617304,0.9910596,0.0008361709,0.0004093165,0.005754701],"study_design_scores_gemma":[0.00002300339,0.0002882586,0.003299226,0.00001774564,0.00003672987,0.0007488326,0.00007966482,0.002874212,0.9735026,0.0004766729,0.01864086,0.00001222928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673788,0.004229886,0.0182395,0.001556562,0.0003048243,0.000099207,0.002386607,0.0002469082,0.005557721],"genre_scores_gemma":[0.9665751,0.002188914,0.01416974,0.0002082602,0.00004431046,0.00003294171,0.008105368,0.00008772183,0.008587513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001283935,"threshold_uncertainty_score":0.00429523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007447783833597089,"score_gpt":0.2137672349755536,"score_spread":0.2063194511419565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}