{"id":"W4399354474","doi":"10.1186/s13293-024-00620-4","title":"Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner","year":2024,"lang":"en","type":"article","venue":"Biology of Sex Differences","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; University of Southern California; Biogen; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Testosterone (patch); Apolipoprotein E; Cognition; Alzheimer's Disease Neuroimaging Initiative; Medicine; Internal medicine; Dementia; Effects of sleep deprivation on cognitive performance; Psychology; Clinical psychology; Physiology; Endocrinology; Disease; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002688399,0.0001298074,0.0003816957,0.0002502888,0.00002193903,0.000004416498,0.00004780269,0.00009625476,0.00006584621],"category_scores_gemma":[0.00008590292,0.00008077569,0.00002483467,0.0002182107,0.0001973402,0.00004897282,0.00004968789,0.0001748829,0.00003100598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004149646,"about_ca_system_score_gemma":0.00003939305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001456403,"about_ca_topic_score_gemma":0.0001716618,"domain_scores_codex":[0.9989558,0.00007648759,0.0002327741,0.0004008645,0.00007513675,0.0002589363],"domain_scores_gemma":[0.999676,0.00009730172,0.00002763449,0.000082933,0.0000511214,0.0000650259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001090627,0.0004087176,0.7556628,0.0001797476,0.0002423689,0.00007623037,0.01499028,0.000001061638,0.0751283,0.0002012569,0.00002197837,0.1519966],"study_design_scores_gemma":[0.0004387755,0.002083315,0.9867545,0.0003266777,0.00002450393,0.000005414721,0.00536111,0.00001217315,0.002847766,0.001959104,0.00008281157,0.0001038694],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963099,0.001619647,0.00001353542,0.00102548,0.0002148548,0.0002534931,0.00002240668,0.00002413778,0.0005165165],"genre_scores_gemma":[0.9989677,0.00008039948,0.00001796563,0.0001228892,0.0001055081,0.0000529203,0.00001095824,0.000007394294,0.0006342643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2310917,"threshold_uncertainty_score":0.3293937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03993129783137728,"score_gpt":0.3001966563121825,"score_spread":0.2602653584808052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}