{"id":"W4399355745","doi":"10.1002/psp4.13167","title":"Physiologically‐based pharmacokinetic modeling of pantoprazole to evaluate the role of <scp>CYP2C19</scp> genetic variation and obesity in the pediatric population","year":2024,"lang":"en","type":"article","venue":"CPT Pharmacometrics & Systems Pharmacology","topic":"Gastroesophageal reflux and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Duke Clinical Research Institute; National Institute of Environmental Health Sciences; University of North Carolina at Chapel Hill; Pennsylvania State University; University of Louisville; University of Pennsylvania; Wichita Medical Research and Education Foundation; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Penn State College of Medicine; Children's Hospital of Philadelphia","keywords":"Dosing; Physiologically based pharmacokinetic modelling; CYP2C19; Pharmacokinetics; Medicine; Pantoprazole; Population; Obesity; Pharmacology; Pharmacodynamics; Internal medicine; Omeprazole; Environmental health; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004547126,0.0005639698,0.0006727605,0.0002522485,0.0001725816,0.0006997809,0.0006277134,0.0008280598,0.001189258],"category_scores_gemma":[0.001683393,0.0003340919,0.001071061,0.0002891297,0.000221054,0.0003680235,0.0003313724,0.0007830704,0.0003213667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006878191,"about_ca_system_score_gemma":0.001278979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01524781,"about_ca_topic_score_gemma":0.006272613,"domain_scores_codex":[0.9997911,0.00007424517,0.00001113302,0.00004488294,0.00005254678,0.00002614867],"domain_scores_gemma":[0.9995458,0.0002650201,0.00007931995,0.00001520025,0.0000770446,0.00001753533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001801487,0.0000942128,0.006410954,0.0001245987,0.0001103857,0.0002413258,0.0000685414,0.975545,0.006141753,0.002527712,0.000981956,0.007573331],"study_design_scores_gemma":[0.00003541651,0.000130252,0.001929438,0.00001325429,0.00005161256,0.0001100938,0.00001531542,0.9946554,0.0006563829,0.0006128883,0.001776361,0.00001367654],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6497429,0.00390512,0.3191442,0.001696053,0.0001517092,0.0004558523,0.00359787,0.0005597413,0.0207464],"genre_scores_gemma":[0.9711822,0.001604384,0.02102173,0.0003328661,0.00002999128,0.0003653541,0.0009712598,0.00006652556,0.004425702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01524781,"threshold_uncertainty_score":0.03031814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02929405519862189,"score_gpt":0.3344661254760887,"score_spread":0.3051720702774668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}