{"id":"W4399358507","doi":"10.1042/bsr20240182","title":"Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells","year":2024,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Receptor tyrosine kinase; Hepatocyte growth factor; Cell biology; Protein kinase B; Signal transduction; Biology; Endosome; Cancer research; Phosphorylation; Endocytic cycle; Receptor; Growth factor receptor; Intracellular; Endocytosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008913267,0.0001727077,0.0001785491,0.000192418,0.0001409215,0.0002592541,0.0001100267,0.0001858837,0.0005510729],"category_scores_gemma":[0.00007978165,0.0001058028,0.0001411779,0.0002217544,0.0001225053,0.0001384077,0.0001178661,0.0002869816,0.0001941358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004668396,"about_ca_system_score_gemma":0.000213814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003198145,"about_ca_topic_score_gemma":0.004508873,"domain_scores_codex":[0.9998776,0.00001635624,0.00001794453,0.00002438226,0.0000407874,0.00002293537],"domain_scores_gemma":[0.9999549,0.000005874717,0.00001515794,0.000007959218,0.000007530909,0.000008536324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006513915,0.00001240021,0.0002241382,0.00002053512,0.000002066784,0.00003327814,0.00001531817,0.00007288661,0.998903,0.00006578782,0.00002744943,0.000558014],"study_design_scores_gemma":[0.00001716592,0.0001860526,0.01087535,0.000004538203,0.00001238879,0.0002252897,0.00004749712,0.001889697,0.983743,0.00002444828,0.002968266,0.000006219824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960555,0.00112296,0.00106675,0.00009234567,0.00002339284,0.00001766412,0.0004698497,0.00005103724,0.001100421],"genre_scores_gemma":[0.99476,0.0007211605,0.001534671,0.00003503373,0.000003790338,0.00002634047,0.0006270656,0.000006863907,0.002285164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003198145,"threshold_uncertainty_score":0.006359041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0114972751781164,"score_gpt":0.2594642729984702,"score_spread":0.2479669978203538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}