{"id":"W4399361575","doi":"10.1016/j.cmet.2024.05.009","title":"Nuclear SMAD5 dances to a different tune in regulating insulin secretion","year":2024,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Transcription factor; Secretion; Beta cell; Insulin; Endocrinology; Type 2 Diabetes Mellitus; Insulin receptor; Fang; Signal transduction; Internal medicine; Cell biology; Biology; Diabetes mellitus; Chemistry; Medicine; Insulin resistance; Genetics; Gene; Islet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005724301,0.0005422578,0.0003358808,0.000656309,0.0004929599,0.001651223,0.0005095391,0.0006976586,0.005460587],"category_scores_gemma":[0.0004322747,0.0003804476,0.0008958188,0.0002092375,0.0009586419,0.0008459202,0.0008939505,0.001271495,0.000889437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005448717,"about_ca_system_score_gemma":0.0004290209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007102533,"about_ca_topic_score_gemma":0.002036829,"domain_scores_codex":[0.9995589,0.00007605329,0.00003251603,0.0001020041,0.00009262231,0.0001379667],"domain_scores_gemma":[0.9997798,0.0000253933,0.00004306762,0.00003248453,0.00003261189,0.00008672752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001830214,0.0001028507,0.004998928,0.0003204202,0.0001791895,0.00047033,0.0002772477,0.0003814138,0.9622394,0.006365296,0.001318409,0.02151635],"study_design_scores_gemma":[0.0004559714,0.001535007,0.1148876,0.0003451164,0.0004442242,0.001804261,0.00305352,0.00378881,0.8173711,0.004947998,0.05121702,0.0001494073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9092093,0.0217898,0.01473281,0.004961609,0.002122624,0.00005105306,0.0007818973,0.0004679533,0.04588306],"genre_scores_gemma":[0.9825339,0.002266151,0.001934722,0.0009335711,0.0001287082,0.00001398618,0.0003217821,0.00006189987,0.0118054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005460587,"threshold_uncertainty_score":0.01826751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134090313553759,"score_gpt":0.2445826529665065,"score_spread":0.2311736216111306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}