{"id":"W4399362618","doi":"10.1038/s41467-024-49025-2","title":"A candidate sex determination locus in amphibians which evolved by structural variation between X- and Y-chromosomes","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Leibniz-Gemeinschaft; University of Crete; National University of Singapore; Leibniz-Institut für Gewässerökologie und Binnenfischerei; Faculty of Science, National University of Singapore; Horizon 2020 Framework Programme; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Heterogametic sex; Biology; Locus (genetics); Genetics; Genome; Y chromosome; Gene; W chromosome; Amphibian; Disorders of sex development; Evolutionary biology; Chromosome; Karyotype; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006931444,0.0001350157,0.0001146026,0.0002499464,0.0001412812,0.0001597399,0.0001233701,0.0001580209,0.00166367],"category_scores_gemma":[0.00007755778,0.0000803671,0.0001086382,0.0001098956,0.0001930957,0.0001026342,0.0001330551,0.0001837089,0.0001959393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336499,"about_ca_system_score_gemma":0.000118417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004004941,"about_ca_topic_score_gemma":0.0005973951,"domain_scores_codex":[0.9999601,0.000002649502,0.000001760407,0.00002052059,0.000008436756,0.000006515485],"domain_scores_gemma":[0.9999543,0.00000464674,0.00002352042,0.000003059719,0.000002791571,0.00001171403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001535266,0.00001360073,0.03150761,0.00009402558,0.00001445692,0.0004516976,0.00008933988,0.00009136977,0.9525777,0.0002752201,0.00008626939,0.01464525],"study_design_scores_gemma":[0.00002503509,0.0003733248,0.7612112,0.00003069356,0.00005758408,0.00705583,0.0002124752,0.0007964147,0.2215294,0.0003511634,0.008343848,0.00001306097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961613,0.0007902149,0.001787205,0.0000472099,0.000004402144,0.000009513248,0.000382264,0.00006005808,0.0007577267],"genre_scores_gemma":[0.9960374,0.0003912049,0.001428296,0.00003327168,0.000005231014,0.000008344832,0.0006460923,0.00001210851,0.001438083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00166367,"threshold_uncertainty_score":0.005565464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009215278339234221,"score_gpt":0.2925222220294976,"score_spread":0.2833069436902633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}