{"id":"W4399365772","doi":"10.3390/cells13110984","title":"Myocardin-Related Transcription Factor Mediates Epithelial Fibrogenesis in Polycystic Kidney Disease","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"RHOA; Polycystic kidney disease; Myocardin; Polycystic kidney; Transcription factor; Fibrosis; Kidney; Cyst; Small GTPase; Cancer research; Medicine; Loss function; Disease; Pathology; Biology; Cell biology; Endocrinology; Internal medicine; Phenotype; Serum response factor; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005880785,0.0001850953,0.0001356869,0.00008176207,0.00003271004,0.0000423471,0.0001304459,0.0001280274,0.0002047141],"category_scores_gemma":[0.00006445258,0.0001711565,0.0001801051,0.0001376525,0.00006207523,0.000004613482,0.000029374,0.00006569072,0.0001658842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001688381,"about_ca_system_score_gemma":0.0002723026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001547635,"about_ca_topic_score_gemma":0.00000194546,"domain_scores_codex":[0.9989106,0.00006300068,0.0002176991,0.0004084641,0.000132523,0.0002676848],"domain_scores_gemma":[0.9992825,0.00001355739,0.00001978997,0.0002284569,0.0000194364,0.0004362931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001157741,0.00005183586,0.0006323998,0.0001156183,0.00005766515,0.00003645613,0.00007347991,0.00006104389,0.9935985,0.00001078307,0.004029251,0.001217257],"study_design_scores_gemma":[0.0008751646,0.0001406247,0.01791934,0.0001519644,0.0001647734,0.000005304038,0.00005856205,0.0007429674,0.9155977,0.0004013499,0.06343734,0.0005048502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874721,0.009553715,0.0002911243,0.0003415667,0.0009986979,0.0002285732,0.0007555949,0.00004800144,0.0003106084],"genre_scores_gemma":[0.9970746,0.0006204275,0.00004989896,0.0002656209,0.0002110837,0.00002965245,0.0004101893,0.00003596164,0.001302553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07800067,"threshold_uncertainty_score":0.697956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006088880994665674,"score_gpt":0.219699742746345,"score_spread":0.2136108617516793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}