{"id":"W4399366218","doi":"10.1124/dmd.124.001705","title":"Modulation of Angiotensin II–Induced Cellular Hypertrophy by Cannflavin-C: Unveiling the Impact on Cytochrome P450 1B1 and Arachidonic Acid Metabolites","year":2024,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Qassim University; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Arachidonic acid; CYP1B1; Hydroxyeicosatetraenoic acid; Cytochrome P450; Internal medicine; Endocrinology; Angiotensin II; Epoxygenase; Muscle hypertrophy; Biology; Chemistry; Enzyme; Biochemistry; Metabolism; Medicine; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002093158,0.0002144951,0.0002635244,0.00008266746,0.0001925638,0.0000517405,0.00007430455,0.000116143,0.00001097583],"category_scores_gemma":[0.00001523983,0.0001374882,0.0001247453,0.0001233443,0.00009493539,0.00001962521,0.00007330037,0.00013013,0.000001637872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006725737,"about_ca_system_score_gemma":0.00003612437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001151507,"about_ca_topic_score_gemma":0.000003384063,"domain_scores_codex":[0.9989546,0.0001258537,0.0002185624,0.0003738656,0.0001245292,0.000202567],"domain_scores_gemma":[0.9995536,0.00002575857,0.00006569493,0.0002024792,0.00006476306,0.00008774945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001171043,0.00005907377,0.00002785124,0.00002045929,0.0001075471,0.000003683618,0.0001455224,0.00005984212,0.9944439,0.0004883474,0.0009480406,0.00357861],"study_design_scores_gemma":[0.00055002,0.0002041814,0.01562726,0.00002834159,0.0002681995,0.00003199502,0.00005493714,0.00489857,0.9750538,0.0003036758,0.002756613,0.0002223458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9584864,0.04019853,0.0001520088,0.0006027464,0.0001428957,0.0002128934,0.0001462192,0.00001601186,0.0000423395],"genre_scores_gemma":[0.9975818,0.001311371,0.000066009,0.0003119019,0.000272462,0.00001422051,0.0003481551,0.00002438513,0.00006963834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0390955,"threshold_uncertainty_score":0.5606605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005842968129523685,"score_gpt":0.2482361982882002,"score_spread":0.2423932301586766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}