{"id":"W4399367382","doi":"10.1158/1078-0432.ccr-23-3552","title":"Concurrent RB1 Loss and <i>BRCA</i> Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma","year":2024,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Vancouver General Hospital; Alberta Health Services; University of British Columbia; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; Foothills Medical Centre; University of Alberta; University of Calgary","funders":"HORIZON EUROPE European Research Council; Medical Research Council; National Center for Advancing Translational Sciences; National Cancer Institute; U.S. Army Medical Research and Development Command; Cancer Institute NSW; Canadian Institutes of Health Research; Janet D. Cottrelle Foundation; Krebsliga Schweiz; Medical Research and Materiel Command; Eisai; Ovarian Cancer Action; AstraZeneca; National Health and Medical Research Council; Cancer Research UK; Swedish Cancer Foundation; Bundesministerium für Bildung und Forschung; Michael Smith Health Research BC; Genentech; Victorian Cancer Agency; Clovis Oncology; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; U.S. Department of Defense","keywords":"Ovarian carcinoma; Ovarian cancer; Biology; Cancer research; Germline; CD8; Transcriptome; Serous carcinoma; Cancer; Immunology; Immune system; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851302,0.0001194017,0.0002127481,0.0002876812,0.0002242143,0.0003164284,0.0001291339,0.0001385753,0.0007480315],"category_scores_gemma":[0.0004058925,0.0000907155,0.0001763247,0.0003203187,0.0001923426,0.0001251236,0.0001892004,0.000168852,0.0001131698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002189518,"about_ca_system_score_gemma":0.000161116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001130846,"about_ca_topic_score_gemma":0.00174807,"domain_scores_codex":[0.9999188,0.00001434816,0.000009124732,0.00002533118,0.00001513411,0.0000171196],"domain_scores_gemma":[0.9997745,0.00004008164,0.0001042126,0.00002279031,0.00001867172,0.00003975751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004902683,0.0000227142,0.9811327,0.00002170747,0.00003828797,0.0001637687,0.00004463239,0.0001246451,0.01458371,0.00001115453,0.00008556431,0.003280733],"study_design_scores_gemma":[0.00001028041,0.0001045064,0.9957075,0.000003972075,0.0000475751,0.0009646508,0.0001005857,0.0004199079,0.002332004,0.00002395004,0.0002831509,0.000002038331],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996589,0.0001245989,0.00005154776,0.000008318086,9.816538e-7,0.000002002203,0.00008361635,0.000003104118,0.00006699682],"genre_scores_gemma":[0.9996769,0.00004168731,0.00006445798,0.000008329762,0.000001598632,0.000002123944,0.0001689022,0.000001161571,0.00003495651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130846,"threshold_uncertainty_score":0.002502441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1430775748915511,"score_gpt":0.46852175686945,"score_spread":0.3254441819778989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}