{"id":"W4399367386","doi":"10.1016/j.jmb.2024.168644","title":"Are Next-Generation Pathogenicity Predictors Applicable to Cancer?","year":2024,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Canada; Institute of Cancer Research; Ontario Institute for Cancer Research; Queen's University","funders":"","keywords":"Pathogenicity; Cancer; Mutation; Computational biology; Biology; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0102664,0.00175507,0.002046556,0.002186709,0.0009079683,0.003009469,0.001855138,0.0020644,0.003511837],"category_scores_gemma":[0.03162258,0.0008808724,0.001556306,0.001362421,0.001319944,0.004422619,0.002428776,0.0047279,0.003611508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008010505,"about_ca_system_score_gemma":0.003572199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003584502,"about_ca_topic_score_gemma":0.006884423,"domain_scores_codex":[0.9953436,0.001956321,0.0002227365,0.0009878415,0.001062057,0.0004273527],"domain_scores_gemma":[0.9832801,0.01146656,0.0008389222,0.001719516,0.001992043,0.000702888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001643927,0.0005334057,0.1543269,0.002935801,0.001463172,0.001188506,0.0005573999,0.08712549,0.02291074,0.01421193,0.07134256,0.6417602],"study_design_scores_gemma":[0.0003553645,0.00182249,0.03811258,0.001924638,0.00119719,0.003755524,0.0008064513,0.6231845,0.04104507,0.1557161,0.1316418,0.0004382963],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2548636,0.1103731,0.5227685,0.04350358,0.005176446,0.000620319,0.01635487,0.02949855,0.01684105],"genre_scores_gemma":[0.7581765,0.02053124,0.1898051,0.007899813,0.001152614,0.000498731,0.01682537,0.001689781,0.003420872],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0102664,"threshold_uncertainty_score":0.05429459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01985358211998143,"score_gpt":0.2899412224507502,"score_spread":0.2700876403307688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}