{"id":"W4399373915","doi":"10.14283/jpad.2024.107","title":"Blood Cathepsins on the Risk of Alzheimer's Disease and Related Pathological Biomarkers: Results from Observational Cohort and Mendelian Randomization Study","year":2024,"lang":"en","type":"article","venue":"The Journal of Prevention of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Natural Science Foundation of China; Ruijin Hospital; Shanghai Municipal Health Commission","keywords":"Mendelian randomization; Observational study; Medicine; Disease; Pathological; Cohort; Cohort study; Dementia; Randomization; Internal medicine; Oncology; Randomized controlled trial; Bioinformatics; Biology; Genetics; Gene; Genetic variants","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002220925,0.0002273257,0.0004438169,0.0001912739,0.0001605623,0.00003747888,0.000138462,0.00005492866,0.0001303535],"category_scores_gemma":[0.0007144068,0.0001170562,0.000309798,0.0002889988,0.0003354135,0.0002000842,0.00007949012,0.0002759971,0.00000418489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001578425,"about_ca_system_score_gemma":0.0003565073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005163395,"about_ca_topic_score_gemma":0.000002141783,"domain_scores_codex":[0.9964703,0.001237334,0.0009700648,0.0002755527,0.0008729668,0.0001738311],"domain_scores_gemma":[0.9973733,0.0008055419,0.0006279705,0.0003955206,0.0003082295,0.0004894091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1227944,0.0179748,0.4804912,0.0001718324,0.3564437,0.001813694,0.003217021,0.0003552305,0.0007174962,0.001098299,0.001881046,0.01304116],"study_design_scores_gemma":[0.009951061,0.001067321,0.9182855,0.0005292394,0.06416799,0.00002174032,0.0003569908,0.001074773,0.0002292122,0.004202499,0.000006410169,0.0001072647],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9324822,0.06353799,0.00002191536,0.001700393,0.00008759068,0.00147931,0.0006122525,0.00001643837,0.00006195687],"genre_scores_gemma":[0.9964343,0.003222838,0.00007155599,0.00003468733,0.0000689896,0.00002205907,0.0001104955,0.00002296817,0.00001209474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4377943,"threshold_uncertainty_score":0.4773413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05422234198164161,"score_gpt":0.328777603143774,"score_spread":0.2745552611621324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}