{"id":"W4399380599","doi":"10.1200/jco.2024.42.16_suppl.5554","title":"Final safety results from ATHENA–MONO (GOG-3020/ENGOT-ov45), a randomized, placebo-controlled, double-blind, phase 3 trial evaluating rucaparib monotherapy as maintenance treatment in patients with newly diagnosed ovarian cancer.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Placebo; Ovarian cancer; Double blind; Randomized controlled trial; Oncology; Internal medicine; Surgery; Cancer; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004054375,0.001119831,0.001465029,0.0004112855,0.0004766597,0.0009879232,0.001030037,0.00185667,0.01252801],"category_scores_gemma":[0.00378644,0.0004705628,0.001474469,0.000366853,0.0004766879,0.0006075675,0.0003651227,0.001926025,0.001721143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000570524,"about_ca_system_score_gemma":0.001315369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006693566,"about_ca_topic_score_gemma":0.002142482,"domain_scores_codex":[0.9989396,0.0006270737,0.00005920173,0.000135732,0.0001441724,0.00009423196],"domain_scores_gemma":[0.9985169,0.0004126338,0.000461422,0.0001319365,0.0001820107,0.0002951524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8230609,0.008091795,0.004338102,0.003232101,0.003398058,0.0004058327,0.0001861844,0.001239956,0.02240375,0.0007406594,0.04514224,0.08776045],"study_design_scores_gemma":[0.8395826,0.1102437,0.01915217,0.0003372673,0.002597674,0.0006095293,0.00005166276,0.00121406,0.003862604,0.0006761567,0.02160558,0.00006706853],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8287016,0.0246821,0.006897615,0.00345224,0.001007044,0.03689523,0.06544251,0.001638313,0.0312833],"genre_scores_gemma":[0.9083757,0.005954653,0.006970009,0.00602191,0.0006080069,0.01623102,0.04287876,0.0002280374,0.01273194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01252801,"threshold_uncertainty_score":0.04191035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1661612356681718,"score_gpt":0.5008747153787974,"score_spread":0.3347134797106255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}