{"id":"W4399383445","doi":"10.1101/2024.06.05.597541","title":"Engineering a SARS-CoV-2 vaccine targeting the RBD cryptic-face via immunofocusing","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Virginia and D.K. Ludwig Fund for Cancer Research","keywords":"Immunodominance; Virology; Antibody; Epitope; Biology; Polyclonal antibodies; Neutralizing antibody; Heterologous; Antigen; Neutralization; Immunology; Virus; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001899124,0.001076216,0.001159724,0.0007084328,0.0003161497,0.000628332,0.001038127,0.0008061915,0.00001891897],"category_scores_gemma":[0.0009601098,0.0008930694,0.0005240685,0.001475593,0.0001188357,0.0001459792,0.002072499,0.003712501,0.0008550566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008742955,"about_ca_system_score_gemma":0.001344255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002492684,"about_ca_topic_score_gemma":0.000002282093,"domain_scores_codex":[0.9946783,0.0001554337,0.001055335,0.00162159,0.001086037,0.001403307],"domain_scores_gemma":[0.9962473,0.0002667298,0.0003210546,0.002329323,0.0007057267,0.0001298492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001131514,0.0001220321,0.000926461,0.001958684,0.000631783,0.0005499013,0.00006570006,0.00003085411,0.9941819,0.0001678354,0.001240885,0.00001084529],"study_design_scores_gemma":[0.0008580452,0.00008152743,0.002592114,0.001700171,0.0004705396,5.334386e-7,0.00001334091,0.009504619,0.9272339,0.000006560947,0.05661487,0.0009237768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790831,0.01186126,0.002378563,0.001197557,0.002280995,0.001798299,0.00006458845,0.001271697,0.00006400389],"genre_scores_gemma":[0.9885105,0.00007403813,0.002697525,0.006391632,0.001585829,0.0003576787,4.334608e-7,0.0003791931,0.000003194786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06694797,"threshold_uncertainty_score":0.9999229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0200933748097028,"score_gpt":0.2762804373006044,"score_spread":0.2561870624909016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}